发明公开
- 专利标题： MULTI-SPECIFIC ANTIBODY CONSTRUCTS
- 专利标题（中）： 多特异性抗体构建体
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申请号： EP15733415.2申请日： 2015-06-25
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公开(公告)号： EP3161008A1公开(公告)日： 2017-05-03
- 发明人: BHATTA, Pallavi , DAVE, Emma , HEYWOOD, Sam Philip , HUMPHREYS, David Paul
- 申请人： UCB Pharma, S.A.
- 申请人地址： 60, allée de la Recherche 1070 Brussels BE
- 专利权人： UCB Pharma, S.A.
- 当前专利权人： UCB Pharma, S.A.
- 当前专利权人地址： 60, allée de la Recherche 1070 Brussels BE
- 代理机构： UCB Intellectual Property
- 优先权： GB201411420 20140626
- 国际公布： WO2015197789 20151230
- 主分类号： C07K16/46
- IPC分类号： C07K16/46
摘要：
The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH1-CH2-CH3-X-(V1)p; and b) a polypeptide chain of formula (II): VL-CL-Y-(V2)q and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multi-specific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multi-specific antibody molecule of the present disclosure from a host cell.
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