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    RECOMBINANT BACTERIAL HOST CELL FOR PROTEIN EXPRESSION
    1.
    发明公开
    RECOMBINANT BACTERIAL HOST CELL FOR PROTEIN EXPRESSION 审中-公开
    复方巴斯伯林紫苏锌蛋白表达

    公开(公告)号：EP2850100A1

    公开(公告)日：2015-03-25

    申请号：EP13723086.8

    申请日：2013-05-13

    申请人： UCB Pharma, S.A.

    发明人： BASSETT, Philip Jonathan ,  HUMPHREYS, David Paul ,  PATEL, Pareshkumar Manjibhai

    IPC分类号： C07K16/24 ,  C12N15/70

    CPC分类号： C12P21/00 ,  C07K16/283 ,  C07K2317/10 ,  C12N9/52 ,  C12N15/70 ,  C12P21/02

    摘要： The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti Fc Rn antibodies and proteins made by the methods described herein.

    摘要翻译： 本公开涉及重组革兰氏阴性细菌细胞，其包含：a）编码具有在一个或多个选自D133，H145，H157，N31，R62，I70，Q73， C94，S95，V98，Q99，R100，L108，Y115，V135，L136，G140，R144和G147，以及b）能够表达或过表达能够促进蛋白质折叠的一种或多种蛋白质的基因，例如FkpA，Skp， SurA，PPiA和PPiD，其中与野生型细胞相比，细胞具有降低的Tsp蛋白活性，使用细胞的方法，使用细胞表达特定抗体的蛋白质，例如抗Fc Rn抗体和由 本文描述的方法。

    MODIFIED ANTIBODY FRAGMENTS
    3.
    发明授权
    MODIFIED ANTIBODY FRAGMENTS 有权
    修饰抗体片段

    公开(公告)号：EP1913026B1

    公开(公告)日：2011-10-05

    申请号：EP06764991.3

    申请日：2006-07-17

    申请人： UCB Pharma S.A.

    发明人： HUMPHREYS, David Paul

    IPC分类号： C07K16/00 ,  A61K47/48

    CPC分类号： C07K16/00 ,  A61K47/60 ,  A61K47/6889 ,  C07K2317/55 ,  C07K2317/624

    摘要： The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region.

    SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES
    4.
    发明公开
    SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES 审中-公开
    SEQUENCE对称修正的双特异性IgG4抗体

    公开(公告)号：EP2817333A1

    公开(公告)日：2014-12-31

    申请号：EP13707824.2

    申请日：2013-02-22

    申请人： UCB Pharma, S.A.

    发明人： HUMPHREYS, David Paul ,  PETERS, Shirley Jane

    IPC分类号： C07K16/00

    摘要： The present disclosure provides an asymmetric mixed antibody comprising two heavy chains or heavy chain fragments each comprising at least a variable region, a hinge region and a CH1 domain, wherein a first heavy chain or fragment thereof is a class IgG4 and has: a the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, and wherein the second heavy chain or fragment thereof is characterised in that part or all of the chain has a different amino acid sequence to said first heavy chain in at least the region outside the variable region (for example the constant region), formulations comprising the same, therapeutic used of both of the above, and processes for preparing the antibodies and formulation.

    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    5.
    发明公开
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权
    BINDUNGSFRAGMENTEN DAVON的ALBUMINBINDENDEANTIKÖRPER

    公开(公告)号：EP2776466A1

    公开(公告)日：2014-09-17

    申请号：EP12801467.7

    申请日：2012-11-09

    申请人： UCB Pharma, S.A.

    发明人： ADAMS, Ralph ,  BHATTA, Pallavi ,  HEYWOOD, Sam Phillip ,  HUMPHREYS, David Paul

    IPC分类号： C07K16/18 ,  C07K16/46 ,  C07K16/28

    CPC分类号： C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

    摘要： A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    摘要翻译： 1.一种血清白蛋白结合抗体或其片段，其包含具有SEQ ID NO：1或SEQ ID NO：2中给出的序列的重链可变结构域和/或包含具有SEQ ID NO：3中给出的序列的轻链可变区或 SEQ ID NO：4，特别包括具有SEQ ID NO：1和SEQ ID NO：3中给出的序列的重链可变结构域和轻链可变结构域或重链可变结构域和具有 SEQ ID NO：2和SEQ ID NO：4中给出的序列。 本公开还延伸到编码抗体或片段的多核苷酸，包含其的载体和能够表达多核苷酸的宿主细胞。 本公开还包括药物组合物，其包含使用其中任何一种的抗体或片段和治疗剂。

    BACTERIAL HOST STRAIN
    6.
    发明公开
    BACTERIAL HOST STRAIN 审中-公开
    细菌宿主菌

    公开(公告)号：EP2480661A1

    公开(公告)日：2012-08-01

    申请号：EP10757621.7

    申请日：2010-09-23

    申请人： UCB Pharma, S.A.

    发明人： ELLIS, Mark ,  HUMPHREYS, David Paul

    IPC分类号： C12N9/50 ,  C12P21/00

    CPC分类号： C12N1/20 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/55 ,  C12N9/52 ,  C12N15/70 ,  C12P21/02 ,  C12R1/19 ,  Y02P20/52

    摘要： A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a. a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b. a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c. a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated Deg P gene and optionally a polynucleotide sequence encoding a protein of interest.

    BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC
    9.
    发明公开
    BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC 有权
    巴布斯新几内亚麻省理工学院DSBC-EXPRESSION

    公开(公告)号：EP2731973A1

    公开(公告)日：2014-05-21

    申请号：EP12737492.4

    申请日：2012-07-13

    申请人： UCB Pharma, S.A.

    发明人： ELLIS, Mark ,  HUMPHREYS, David Paul

    IPC分类号： C07K16/28 ,  C12N15/70

    CPC分类号： C07K16/2875 ,  C07K2317/14 ,  C07K2317/55 ,  C12N9/90

    摘要： The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector, comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen binding fragment thereof specifically binding to CD154.

    摘要翻译： 本发明提供了包含表达载体的重组革兰氏阴性细菌细胞，其包含编码DsbC的重组多核苷酸和编码与CD154特异性结合的抗体或其抗原结合片段的一种或多种多核苷酸。