An implant with anchoring device for heart valve disease comprises a cardiac valve prosthesis (1), at least two sets of anchoring needles (2) and at least two sets of anchoring needle releasing devices (3). Proximal end of the anchoring needles (2) are provided with anti-disengagement ends (23). The anchoring needle releasing devices (3) are detachably connected to the cardiac valve prosthesis (1). The anchoring needle releasing devices (3) comprise delivery tubes (31) and shafts (32). Distal sections of the anchoring needle releasing devices (3) are in preset shapes, so that distal sections (3112, 3122) of the delivery tubes (31) can bend wholly or partially. Bendable parts of the delivery tubes (31) are bent sections (31121, 31221), and the most distal ends of the delivery tubes (31) are rigid sections. The length from the most distal end of the delivery tube (31) to the most proximal end of the bent section (31121, 31221) is larger than or equal to 1/6 of the circumference of a circle formed by the minimum radius of a native heart valve annulus of a patient. The anchoring needles (2) are pre-placed inside the distal sections (3112, 3122) of the delivery tubes (31) and are located at the distal ends of the shafts (32). The shafts (32) can be pushed to force the anchoring needles (2) to move toward the distal ends of the delivery tubes (31), so that the cardiac valve prosthesis (1) is fixed between autogenous tissue (6) and the anti-disengagement ends (23) to achieve accurate positioning and firm anchoring of the cardiac valve prosthesis (1).