公开(公告)号：EP3520735A1

公开(公告)日：2019-08-07

申请号：EP17863597.5

申请日：2017-10-23

申请人： Ningbo Jenscare Biotechnology Co., Ltd.

发明人： LV, Shiwen ,  LI, Yibin ,  XU, Zhiyun ,  CHEN, Zhi ,  LU, Fanglin ,  LI, Jianan

IPC分类号： A61F2/24

摘要： The invention relates to a heart valve prosthesis (100, 200, 300, 400, 500) anchored to an interventricular septum (183, 383). The heart valve prosthesis (100, 200, 300, 400, 500) comprises a valve supporting frame (110, 210, 310) and a fixing device (113, 213, 313, 518). The valve supporting frame (110, 210, 310) comprises a valve stitching section (112, 212, 312, 412, 512) and an artificial valve (120, 520), and the artificial valve (120, 520) is fixedly connected to the valve stitching section (112, 212, 312, 412, 512); the fixing device (113, 213, 313, 518) comprises a fixing and supporting section (114, 214, 314, 514) and a fixing member (115, 215, 315, 415, 515), one end of the fixing and supporting section (114, 214, 314, 514) is connected to a proximal end of the valve stitching section (112, 212, 312, 412, 512), and another end of the fixing and supporting section (114, 214, 314, 514) is connected to the interventricular septum (183, 383) of a patient by the fixing member (115, 215, 315, 415, 515), to support the heart valve prosthesis (100, 200, 300, 400, 500) and prevent the heart valve prosthesis (100, 200, 300, 400, 500) from axially moving.

公开(公告)号：EP3167850A1

公开(公告)日：2017-05-17

申请号：EP15819076.9

申请日：2015-05-29

申请人： Ningbo Jenscare Biotechnology Co., Ltd.

发明人： LI, Jianan ,  LV, Shiwen ,  XU, Zhiyun ,  LI, Yibin ,  CHEN, Zhi

IPC分类号： A61F2/966

摘要： An implant with anchoring device for heart valve disease comprises a cardiac valve prosthesis (1), at least two sets of anchoring needles (2) and at least two sets of anchoring needle releasing devices (3). Proximal end of the anchoring needles (2) are provided with anti-disengagement ends (23). The anchoring needle releasing devices (3) are detachably connected to the cardiac valve prosthesis (1). The anchoring needle releasing devices (3) comprise delivery tubes (31) and shafts (32). Distal sections of the anchoring needle releasing devices (3) are in preset shapes, so that distal sections (3112, 3122) of the delivery tubes (31) can bend wholly or partially. Bendable parts of the delivery tubes (31) are bent sections (31121, 31221), and the most distal ends of the delivery tubes (31) are rigid sections. The length from the most distal end of the delivery tube (31) to the most proximal end of the bent section (31121, 31221) is larger than or equal to 1/6 of the circumference of a circle formed by the minimum radius of a native heart valve annulus of a patient. The anchoring needles (2) are pre-placed inside the distal sections (3112, 3122) of the delivery tubes (31) and are located at the distal ends of the shafts (32). The shafts (32) can be pushed to force the anchoring needles (2) to move toward the distal ends of the delivery tubes (31), so that the cardiac valve prosthesis (1) is fixed between autogenous tissue (6) and the anti-disengagement ends (23) to achieve accurate positioning and firm anchoring of the cardiac valve prosthesis (1).

摘要翻译： 具有用于心脏瓣膜疾病的锚定装置的植入物包括心脏瓣膜假体（1），至少两组锚定针（2）和至少两组锚定释放装置（3）。 锚定针（2）的近端设有防脱离端（23）。 锚定针释放装置（3）可拆卸地连接到心脏瓣膜假体（1）。 锚定针释放装置（3）包括输送管（31）和轴（32）。 锚定针释放装置（3）的远端部分处于预设形状，使得输送管（31）的远端部分（3112,3122）可以完全或部分地弯曲。 输送管（31）的可弯曲部分是弯曲部分（31121,31221），并且输送管（31）的最远端是刚性部分。 从输送管（31）的最远端到弯曲部分（31121,31221）的最近端的长度大于或等于由最小半径a形成的圆的周长的1/6 天生的心脏瓣膜瓣环。 锚定针（2）预先放置在输送管（31）的远端部分（3112,3122）内并位于轴（32）的远端处。 可以推动轴（32）以迫使锚定针（2）朝向输送管（31）的远端移动，使得心脏瓣膜假体（1）固定在自体组织（6）和防止 - 分离端（23）以实现心脏瓣膜假体（1）的精确定位和牢固锚定。

公开(公告)号：EP3892239A1

公开(公告)日：2021-10-13

申请号：EP19892776.6

申请日：2019-11-28

申请人： Ningbo Jenscare Biotechnology Co., Ltd.

发明人： LV, Shiwen ,  LI, Yibin ,  CHEN, Zhi ,  LU, Kan

IPC分类号： A61F2/24

摘要： The present application relates to a transcatheter prosthetic valve replacement system including a delivery catheter, a frame, a prosthetic valve, and one or more clamping devices. The prosthetic valve is fixed in the frame. The clamping device is connected to a periphery of the frame. The frame and the clamping device can be preloaded in the delivery catheter. The clamping device includes a clamping member, a collar, and a control member. One end of the clamping member is a fixation end which is fixedly connected to the frame, and the other end of the clamping member is a deployable resilient segment which can be compressed and released. The collar is slidably sleeved on the clamping member. One end of the control member is connected to the collar, and the other end of the control member is manipulated outside the body. From being compressed to being fully released, the clamping member in sequence has two configurations. In the first configuration, the collar is moved along the clamping member towards a free end of the deployable resilient segment, and the deployable resilient segment is gradually closed. In the second configuration, the collar is moved along the deployable resilient segment towards the fixation end, and the deployable resilient segment recovers its predetermined shape.

公开(公告)号：EP3895661A1

公开(公告)日：2021-10-20

申请号：EP19895646.8

申请日：2019-11-28

申请人： Ningbo Jenscare Biotechnology Co., Ltd.

发明人： LI, Yibin ,  ZHENG, Linghe ,  LV, Shiwen

IPC分类号： A61F2/24

摘要： The present application relates to a separately releasable aortic valve stent, which includes a valve sewing segment, a positioning member, and a prosthetic valve. The prosthetic valve is connected to the valve sewing segment. The valve sewing segment and the positioning member are two independent components and connected to each other via a guiding device. The positioning member is able to be released prior to the valve sewing segment. A slide connection structure is disposed on the valve sewing segment. One end of the guiding device is connected to the positioning member, and another end of the guiding device passed through the slide connection structure is connected to the positioning member. The valve sewing segment is slidable along the guiding device. The positions of the main stent and the positioning member can be effectively controlled, and the blockage of the coronary artery can be effectively prevented.

公开(公告)号：EP3892238A1

公开(公告)日：2021-10-13

申请号：EP19892150.4

申请日：2019-11-28

申请人： Ningbo Jenscare Biotechnology Co., Ltd.

发明人： LV, Shiwen ,  LI, Yibin ,  CHEN, Zhi ,  LU, Kan

IPC分类号： A61F2/24

摘要： The present application relates to a stepwise-clamping type valve prosthesis including a frame body and a clamping member. The frame body has a channel allowing blood to flow therethrough. The clamping member includes a first clamping member and a second clamping member. One end of the first clamping member is connected to the frame body, and the other end of the first clamping member is a free end. The second clamping member is connected to the first clamping member. The clamping member has three states in sequence from being restricted to being fully released. In the first state, the first clamping member and the second clamping member are both restricted. In the second state, the second clamping member is restricted, and the first clamping member extends in a radial direction of the frame body and is capable of reaching a position between a valve leaflet and a heart wall. In the third state, the second clamping member protrudes from the first clamping member and extends in a circumferential direction of the frame body and abuts against an outer surface of the frame body, so that an autologous valve leaflet and adjacent tissues are capable of being clamped between the second clamping member, the first clamping member, and the frame body. The contact area between the valve prosthesis and the autologous tissues can be increased, the position stability of the valve prosthesis in the heart can be improved, and the success rate of the operation can be increased.

公开(公告)号：EP4241735A2

公开(公告)日：2023-09-13

申请号：EP23171822.2

申请日：2017-10-23

申请人： Ningbo Jenscare Biotechnology Co., Ltd.

发明人： LV, Shiwen ,  LI, Yibin ,  XU, Zhiyun ,  CHEN, Zhi ,  LU, Fanglin ,  LI, Jianan

IPC分类号： A61F2/24

摘要： The invention relates to a heart valve prosthesis (100, 200, 300, 400, 500) anchored to an interventricular septum (183, 383) and conveying and releasing method thereof. The heart valve prosthesis (100, 200, 300, 400, 500) comprises a valve supporting frame (110, 210, 310) and a fixing device (113, 213, 313). The valve supporting frame (110, 210, 310) comprises a valve stitching section (112, 212, 312, 412, 512) and an artificial valve (120, 520), and the artificial valve (120, 520) is fixedly connected to the valve stitching section (112, 212, 312, 412, 512); the fixing device (113, 213, 313) comprises a fixing and supporting section (114, 214, 314, 514) and a fixing member (115, 215, 315, 415, 515), one end of the fixing and supporting section (114, 214, 314, 514) is connected to a proximal end of the valve stitching section (112, 212, 312, 412, 512), and another end of the fixing and supporting section (114, 214, 314, 514) is connected to the interventricular septum (183, 383) of a patient by the fixing member (115, 215, 315, 415, 515), to support the heart valve prosthesis (100, 200, 300, 400, 500) and prevent the heart valve prosthesis (100, 200, 300, 400, 500) from axially moving.

公开(公告)号：EP3167850B1

公开(公告)日：2019-11-27

申请号：EP15819076.9

申请日：2015-05-29

申请人： Ningbo Jenscare Biotechnology Co., Ltd.

发明人： LI, Jianan ,  LV, Shiwen ,  XU, Zhiyun ,  LI, Yibin ,  CHEN, Zhi

IPC分类号： A61F2/966

公开(公告)号：EP3167846A1

公开(公告)日：2017-05-17

申请号：EP15819710.3

申请日：2015-05-29

申请人： Ningbo Jenscare Biotechnology Co., Ltd.

发明人： LI, Yibin ,  LV, Shiwen ,  XU, Zhiyun ,  LI, Jianan ,  ZHENG, Deyuan ,  CHEN, Zhi

IPC分类号： A61F2/24

CPC分类号： A61F2/246 ,  A61F2/2445 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2250/0004

摘要： A prosthesis (100) for preventing a valve regurgitation, comprising a fixation unit (110), a connection piece (120) and a closure assisting piece (130); the fixation unit (110) comprises a fixation piece (111) and an anchor (112); the connection piece (120) is flexible, and a distal section thereof is connected to a proximal section of the fixation piece (111), and a proximal section thereof is connected to a distal section of the closure assisting piece (130); the fixation piece (111) is fixed on the atrial wall or a valve ring of a patient via the anchor (112); the deployed width of the fixation piece (111) is less than two-thirds of the circumference of a valve tissue annulus; the closure assisting piece (130) is located between autologous valve leaflets of the patient when in a free state; the maximum width of the closure assisting piece (130) is less than the maximum deployed width of a single autologous valve leaflet; and the proximal end of the anchor (112) is provided with an anti-disengagement end (1120). The position of the prosthesis (100) can be adjusted, and the prosthesis (100) is accurately positioned and firmly anchored, and does not readily adhere to tissue adjacent to the valve annulus of the patient.

摘要翻译： 1。一种用于防止瓣膜反流的假体（100），包括固定单元（110），连接件（120）和闭合件辅助件（130）; 所述固定单元（110）包括固定件（111）和锚定件（112）。 所述连接件120是柔性的，并且其远端部分连接到所述固定件111的近端部分，并且其近端部分连接到所述封闭件辅助件130的远端部分; 固定片111通过锚固件112固定在患者的心房壁或瓣环上; 固定件（111）的展开宽度小于瓣膜组织瓣环的周长的三分之二; 当处于自由状态时，封闭辅助件（130）位于患者的自体瓣膜小叶之间; 封闭辅助件（130）的最大宽度小于单个自体瓣膜小叶的最大展开宽度; 并且锚（112）的近端设置有防脱离端（1120）。 可以调节假体（100）的位置，并且假体（100）被精确地定位并牢固地锚定，并且不容易粘附到与患者的瓣膜瓣环相邻的组织。