发明公开
- 专利标题： PREPARATION OF A SOLID FORM OF GADOBENATE DIMEGLUMINE
- 专利标题（中）： 制备固体形式的胆固醇二甲亮氨酸
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申请号： EP15738381.1申请日： 2015-07-20
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公开(公告)号： EP3172186A1公开(公告)日： 2017-05-31
- 发明人: MAZZON, Roberta , FRETTA, Roberta , ANELLI, Pier Lucio
- 申请人： Bracco Imaging S.p.A.
- 申请人地址： Via Egidio Folli 50 20134 Milano IT
- 专利权人： Bracco Imaging S.p.A.
- 当前专利权人： Bracco Imaging S.p.A.
- 当前专利权人地址： Via Egidio Folli 50 20134 Milano IT
- 代理机构： Ravizza, Claudio
- 优先权： EP14178283 20140724
- 国际公布： WO2016012386 20160128
- 主分类号： C07C227/38
- IPC分类号： C07C227/38 ; A61K9/00
摘要：
The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that essentially comprises obtaining a solution of the said compound in a suitable solvent A and adding, under stirring and appropriate temperature conditions, the said obtained solution in a suitable organic solvent B, acting as an appropriate antisolvent and favoring the formation and precipitation of solid particles of the complex compound that can be easily collected by filtration in high yields and in a reliable way.
公开/授权文献
- EP3172186B1 PREPARATION OF A SOLID FORM OF GADOBENATE DIMEGLUMINE 公开/授权日：2018-09-12
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