公开(公告)号：EP2421819B1

公开(公告)日：2014-03-05

申请号：EP10718104.2

申请日：2010-04-08

申请人： Bracco Imaging S.p.A

发明人： CITTERIO, Attilio ,  LATTUADA, Luciano ,  FERRIGATO, Aurelia ,  FRETTA, Roberta ,  MAZZON, Roberta ,  MELI, Gabriele ,  LEONARDI, Gabriella ,  UGGERI, Fulvio ,  VIGNALE, Evelin ,  VISIGALLI, Massimo

IPC分类号： C07C227/16

CPC分类号： C07C227/16 ,  C07C229/62

公开(公告)号：EP2408735A1

公开(公告)日：2012-01-25

申请号：EP10708209.1

申请日：2010-03-12

申请人： Bracco Imaging S.p.A

发明人： ANELLI, Pier Lucio ,  BROCCHETTA, Marino ,  FRETTA, Roberta ,  LATTUADA, Luciano ,  MORTILLARO, Armando

IPC分类号： C07C231/10 ,  C07C235/16 ,  C07C237/52

CPC分类号： C07C237/46 ,  C07C231/02 ,  C07C231/10 ,  C07C235/16

摘要： The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available α-hydroxyacid or a salt thereof.

公开(公告)号：EP3154928A1

公开(公告)日：2017-04-19

申请号：EP15727005.9

申请日：2015-06-10

申请人： Bracco Imaging S.p.A.

发明人： FRETTA, Roberta ,  VISCARDI, Carlo Felice ,  DELOGU, Pietro ,  NARDELLI, Alfonso ,  SGUASSERO, Stefano ,  DI GIORGIO, Fernanda

IPC分类号： C07C59/08 ,  C07C51/377 ,  C07C69/22 ,  C07C69/675

摘要： The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.

摘要翻译： 本发明涉及将乳酸水溶液乙酰化成（S）-2-乙酰氧基丙酸的方法。 该方法特别是在乙酸存在下，从乳酸溶液中除去水分，并将乳酸与乙酸酐反应。

公开(公告)号：EP3634908A1

公开(公告)日：2020-04-15

申请号：EP18728179.5

申请日：2018-06-07

申请人： Bracco Imaging S.p.A.

发明人： GALIMBERTI, Laura ,  BANIN, Andrea ,  GAZZETTO, Sonia ,  DI GIORGIO, Fernanda ,  FRETTA, Roberta

IPC分类号： C01B7/14

公开(公告)号：EP3154928B1

公开(公告)日：2020-03-04

申请号：EP15727005.9

申请日：2015-06-10

申请人： Bracco Imaging S.p.A.

发明人： FRETTA, Roberta ,  VISCARDI, Carlo Felice ,  DELOGU, Pietro ,  NARDELLI, Alfonso ,  SGUASSERO, Stefano ,  DI GIORGIO, Fernanda

IPC分类号： C07C67/08 ,  C07C67/287 ,  C07C51/44

公开(公告)号：EP2421819A1

公开(公告)日：2012-02-29

申请号：EP10718104.2

申请日：2010-04-08

申请人： Bracco Imaging S.p.A

发明人： CITTERIO, Attilio ,  LATTUADA, Luciano ,  FERRIGATO, Aurelia ,  FRETTA, Roberta ,  MAZZON, Roberta ,  MELI, Gabriele ,  LEONARDI, Gabriella ,  UGGERI, Fulvio ,  VIGNALE, Evelin ,  VISIGALLI, Massimo

IPC分类号： C07C227/16

CPC分类号： C07C227/16 ,  C07C229/62

摘要： The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5- disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

公开(公告)号：EP3172186B1

公开(公告)日：2018-09-12

申请号：EP15738381.1

申请日：2015-07-20

申请人： Bracco Imaging S.p.A.

发明人： MAZZON, Roberta ,  FRETTA, Roberta ,  ANELLI, Pier Lucio

IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K49/10 ,  A61K49/18 ,  C07C227/40 ,  C07F5/00

CPC分类号： C07F5/003 ,  A61K9/0019 ,  A61K9/14 ,  A61K49/101 ,  A61K49/1818 ,  C07C227/40

摘要： The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that essentially comprises obtaining a solution of the said compound in a suitable solvent A and adding, under stirring and appropriate temperature conditions, the said obtained solution in a suitable organic solvent B, acting as an appropriate antisolvent and favoring the formation and precipitation of solid particles of the complex compound that can be easily collected by filtration in high yields and in a reliable way.

公开(公告)号：EP3172186A1

公开(公告)日：2017-05-31

申请号：EP15738381.1

申请日：2015-07-20

申请人： Bracco Imaging S.p.A.

发明人： MAZZON, Roberta ,  FRETTA, Roberta ,  ANELLI, Pier Lucio

IPC分类号： C07C227/38 ,  A61K9/00

CPC分类号： C07F5/003 ,  A61K9/0019 ,  A61K9/14 ,  A61K49/101 ,  A61K49/1818 ,  C07C227/40

摘要： The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that essentially comprises obtaining a solution of the said compound in a suitable solvent A and adding, under stirring and appropriate temperature conditions, the said obtained solution in a suitable organic solvent B, acting as an appropriate antisolvent and favoring the formation and precipitation of solid particles of the complex compound that can be easily collected by filtration in high yields and in a reliable way.

摘要翻译： 本发明涉及制备固体形式的钆二硫代葡萄糖胺化合物的方法，其基本上包括获得所述化合物在合适的溶剂A中的溶液，并在搅拌和适当的温度条件下将所述获得的溶液加入 合适的有机溶剂B，充当合适的反溶剂并有助于形成和沉淀配合物的固体颗粒，该配合物可通过过滤以高收率和可靠的方式容易地收集。

公开(公告)号：EP2408735B1

公开(公告)日：2013-06-05

申请号：EP10708209.1

申请日：2010-03-12

申请人： Bracco Imaging S.p.A

发明人： ANELLI, Pier Lucio ,  BROCCHETTA, Marino ,  FRETTA, Roberta ,  LATTUADA, Luciano ,  MORTILLARO, Armando

IPC分类号： C07C231/10 ,  C07C231/02 ,  C07C235/16 ,  C07C237/46

CPC分类号： C07C237/46 ,  C07C231/02 ,  C07C231/10 ,  C07C235/16