发明公开
EP3175854A4 A USE OF ALKALOID IN PREPARING PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING PULMONARY FIBROSIS
审中-公开
VERWENDUNG VON ALKALOID贝德赫斯通公司VAR PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN ZUR VORBEUGUNG ODER BEHANDLUNG VON LUNGENFIBROSE
- 专利标题： A USE OF ALKALOID IN PREPARING PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING PULMONARY FIBROSIS
- 专利标题（中）： VERWENDUNG VON ALKALOID贝德赫斯通公司VAR PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN ZUR VORBEUGUNG ODER BEHANDLUNG VON LUNGENFIBROSE
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申请号： EP15827281申请日： 2015-06-17
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公开(公告)号： EP3175854A4公开(公告)日： 2017-09-13
- 发明人: ZHANG MIAN , XU XIANGHONG , XIANG JUAN , ZHANG CHAOFENG , HE YANHUI , WU YAN
- 申请人： JIANGSU KANION PARMACEUTICAL CO LTD , UNIV CHINA PHARMA
- 专利权人： JIANGSU KANION PARMACEUTICAL CO LTD,UNIV CHINA PHARMA
- 当前专利权人： JIANGSU KANION PARMACEUTICAL CO LTD,UNIV CHINA PHARMA
- 优先权： CN201410376837 2014-07-30
- 主分类号： A61K31/553
- IPC分类号： A61K31/553 ; A61P11/00 ; C07D491/16
摘要：
Disclosed is a new use of a compound as indicated in structural formula I in preparing medications for preventing and/or treating pulmonary fibrosis. The compound having the structure as indicated in structural formula 1 substantially reduces the inflammation of diseased lung tissue, lowers the concentration of fibrosis factors TGF-²l in diseased lung tissue, decreases the excessive deposition of collagen in diseased lung tissue, and has substantial prevention and treatment effectiveness against fibrosis.
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