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    A USE OF ALKALOID IN PREPARING PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING PULMONARY FIBROSIS
    1.
    发明公开
    A USE OF ALKALOID IN PREPARING PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING PULMONARY FIBROSIS 审中-公开
    VERWENDUNG VON ALKALOID贝德赫斯通公司VAR PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN ZUR VORBEUGUNG ODER BEHANDLUNG VON LUNGENFIBROSE

    公开(公告)号：EP3175854A4

    公开(公告)日：2017-09-13

    申请号：EP15827281

    申请日：2015-06-17

    申请人： JIANGSU KANION PARMACEUTICAL CO LTD ,  UNIV CHINA PHARMA

    发明人： ZHANG MIAN ,  XU XIANGHONG ,  XIANG JUAN ,  ZHANG CHAOFENG ,  HE YANHUI ,  WU YAN

    IPC分类号： A61K31/553 ,  A61P11/00 ,  C07D491/16

    CPC分类号： A61K31/55 ,  A61K31/553 ,  C07D491/16

    摘要： Disclosed is a new use of a compound as indicated in structural formula I in preparing medications for preventing and/or treating pulmonary fibrosis. The compound having the structure as indicated in structural formula 1 substantially reduces the inflammation of diseased lung tissue, lowers the concentration of fibrosis factors TGF-²l in diseased lung tissue, decreases the excessive deposition of collagen in diseased lung tissue, and has substantial prevention and treatment effectiveness against fibrosis.

    摘要翻译： 公开了如结构式I所示的化合物在制备用于预防和/或治疗肺纤维化的药物中的新用途。 具有结构式1所示结构的化合物基本上减少患病肺组织的炎症，降低患病肺组织中纤维化因子TGF-β1的浓度，减少胶原在患病肺组织中的过度沉积，并且具有实质性的预防和 治疗纤维化的有效性。