- 专利标题: [5,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS
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申请号: EP15829495申请日: 2015-08-03
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公开(公告)号: EP3177285A4公开(公告)日: 2018-02-14
- 发明人: CHEN HELEN Y , DEMONG DUANE , FINKE PAUL E , PLUMMER CHRISTOPHER W
- 申请人: MERCK SHARP & DOHME
- 专利权人: MERCK SHARP & DOHME
- 当前专利权人: MERCK SHARP & DOHME
- 优先权: US201462034809 2014-08-08
- 主分类号: A61K31/343
- IPC分类号: A61K31/343 ; A61K31/443 ; C07D307/80 ; C07D405/04 ; C07D405/10
摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
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