公开(公告)号：EP3177285A4

公开(公告)日：2018-02-14

申请号：EP15829495

申请日：2015-08-03

申请人： MERCK SHARP & DOHME

发明人： CHEN HELEN Y ,  DEMONG DUANE ,  FINKE PAUL E ,  PLUMMER CHRISTOPHER W

IPC分类号： A61K31/343 ,  A61K31/443 ,  C07D307/80 ,  C07D405/04 ,  C07D405/10

CPC分类号： C07D405/04 ,  A61K31/343 ,  A61K31/443 ,  A61K45/06 ,  C07D307/80 ,  C07D405/10 ,  A61K2300/00

摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

公开(公告)号：EP3097101A4

公开(公告)日：2017-06-07

申请号：EP15740935

申请日：2015-01-20

申请人： MERCK SHARP & DOHME

发明人： BERGER RICHARD ,  BLIZZARD TIMOTHY A ,  CAMPBELL BRIAN T ,  CHEN HELEN Y ,  DEBENHAM JOHN S ,  DEWNANI SUNITA V ,  DUBOIS BYRON ,  GUDE CANDIDO ,  GUO ZHIQIANG ,  HARPER BART ,  HU ZHIYONG ,  LIN SONGNIAN ,  LIU PING ,  WANG MING ,  UJJAINWALLA FEROZE ,  XU JIAYI ,  XU LIBO ,  ZHANG RUI

IPC分类号： C07D471/04

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04

摘要： The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

摘要翻译： 式I化合物起到MGAT2抑制剂的作用，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的治疗剂。