发明公开
- 专利标题: ANTIDIABETIC BICYCLIC COMPOUNDS
- 专利标题(中): 抗糖尿病双环化合物
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申请号: EP15830117.6申请日: 2015-08-06
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公开(公告)号: EP3177287A1公开(公告)日: 2017-06-14
- 发明人: CHEN, Helen , COLLETTI, Steven L. , DEMONG, Duane , GUO, Yan , MILLER, Michael , NAIR, Anilkumar , PLUMMER, Christopher W. , XIAO, Dong , YANG, De-Yi
- 申请人: Merck Sharp & Dohme Corp.
- 申请人地址: 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构: Böhles, Elena
- 优先权: US201462034820P 20140808
- 国际公布: WO2016022742 20160211
- 主分类号: A61K31/357
- IPC分类号: A61K31/357
摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
公开/授权文献
- EP3177287B1 ANTIDIABETIC BICYCLIC COMPOUNDS 公开/授权日:2022-02-23
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