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公开(公告)号：EP3558298A1
公开(公告)日：2019-10-30
申请号：EP17884985.7
申请日：2017-12-15
发明人： MILLER, Michael , CHOBANIAN, Harry, R. , HE, Shuwen , HAO, Jinsong , PIO, Barbara , GUO, Yan , XIAO, Dong
IPC分类号： A61K31/352 , A61K31/353 , A61K31/445
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公开(公告)号：EP3068768B1
公开(公告)日：2019-07-31
申请号：EP14862098.2
申请日：2014-11-10
发明人： BIFTU, Tesfaye , BIJU, Purakkattle , COLLETTI, Steven L. , DANG, Qun , DHONDI, Pawan K. , GUDE, Candido , JOSIEN, Hubert , KAR, Nam Fung , NAIR, Anilkumar G. , NARGUND, Ravi P. , YANG, De-Yi , XIAO, Dong , ZHU, Cheng
IPC分类号： C07D221/16 , C07D487/10 , C07D487/04 , C07D401/12 , A61K31/435 , A61P3/10
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3.发明授权
公开(公告)号：EP2953456B1
公开(公告)日：2019-05-22
申请号：EP14748737.5
申请日：2014-02-03
发明人： DAI, Xing , LIU, Hong , PALANI, Anandan , HE, Shuwen , BROCKUNIER, Linda, L. , NARGUND, Ravi , MARCANTONIO, Karen , ZORN, Nicolas , XIAO, Dong , PENG, Xuanjia , LI, Peng , GUO, Tao
IPC分类号： A61K31/397 , C07D487/14 , C07D471/04 , C07D471/14 , C07D471/20 , C07D471/22 , C07D519/00
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4.发明授权
公开(公告)号：EP2753325B1
公开(公告)日：2018-09-19
申请号：EP12830590.1
申请日：2012-08-20
发明人： MCCOMAS, Casey Cameron , LIVERTON, Nigel J. , HABERMANN, Joerg , KOCH, Uwe , NARJES, Frank , LI, Peng , PENG, Xuanjia , SOLL, Richard , WU, Hao , PALANI, Anandan , HE, Shuwen , DAI, Xing , LIU, Hong , LAI, Zhong , LONDON, Clare , XIAO, Dong , ZORN, Nicolas , NARGUND, Ravi
IPC分类号： A61K31/343 , C07D307/82 , C07D405/10 , A61P31/14
CPC分类号： A61K31/553 , A61K31/407 , A61K31/437 , A61K31/519 , A61K31/5365 , A61K45/06 , C07D491/052 , C07D491/147 , C07D498/04 , C07D498/14 , C07D498/22 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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公开(公告)号：EP2661428B1
公开(公告)日：2017-06-07
申请号：EP11851281.3
申请日：2011-12-19
发明人： BOYCE, Christopher W. , DEGRADO, Sylvia Joanna , CHEN, Xiao , QIN, Jun , MAZZOLA, Robert D., Jr. , YU, Younong , MCCORMIC, Kevin D. , PALANI, Anandan , XIAO, Dong , ASLANIAN, Robert George , WU, Jie , RAO, Ashwin Umesh , SILIPHAIVANH, Phieng , METHOD, Joe Lee , ZHANG, Hongjun , KELLEY, Elizabeth Helen , BROWN, William Colby , JIANG, Qin , GAUUAN, Jolicia Polivina , LEYHANE, Andrew J. , BIJU, Purakkattle Johny , DHONDI, Pawan K. , DONG, Li , FEVRIER, Salem , HUANG, Xianhai , VACCARO, Henry M.
IPC分类号： C07D241/42 , C07D241/44 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D498/04 , A61K31/498 , A61P11/02 , A61P11/06 , A61P11/14
CPC分类号： C07D241/42 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/55 , A61K45/06 , C07D241/38 , C07D241/44 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/107 , C07D498/04 , C07D498/10
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公开(公告)号：EP3102198A1
公开(公告)日：2016-12-14
申请号：EP15745823.3
申请日：2015-02-03
发明人： CHOBANIAN, Harry , DEMONG, Duane , GUO, Yan , HU, Zhiyong , MILLER, Michael , PIO, Barbara , PLUMMER, Christopher, W. , XIAO, Dong , YANG, Cangming , ZHANG, Rui
CPC分类号： C07D211/42 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/4985 , A61K45/06 , C07C59/72 , C07C217/52 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D205/12 , C07D207/08 , C07D207/10 , C07D207/12 , C07D209/52 , C07D209/54 , C07D211/22 , C07D213/30 , C07D213/64 , C07D213/647 , C07D213/65 , C07D213/69 , C07D231/20 , C07D239/52 , C07D265/30 , C07D307/86 , C07D307/88 , C07D401/04 , C07D491/056 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译： 结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体 受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和 高甘油三酯血症。
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公开(公告)号：EP3068768A1
公开(公告)日：2016-09-21
申请号：EP14862098.2
申请日：2014-11-10
发明人： BIFTU, Tesfaye , BIJU, Purakkattle , COLLETTI, Steven L. , DANG, Qun , DHONDI, Pawan K. , GUDE, Candido , JOSIEN, Hubert , KAR, Nam Fung , NAIR, Anilkumar G. , NARGUND, Ravi P. , YANG, De-Yi , XIAO, Dong , ZHU, Cheng
IPC分类号： C07D221/16
CPC分类号： C07D221/16 , A61K9/20 , A61K31/435 , A61K31/444 , A61K31/4545 , A61K45/06 , C07D401/12 , C07D487/04 , C07D487/10
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译： 结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体 受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和 高甘油三酯血症。
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8.发明公开SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开取代的苯并呋喃和方法及其用于病毒病的治疗
公开(公告)号：EP3013334A1
公开(公告)日：2016-05-04
申请号：EP14816866.9
申请日：2014-06-19
发明人： LIU, Hong , DAI, Xing , PALANI, Anandan , HE, Shuwen , NARGUND, Ravi , XIAO, Dong , DANG, Qun , PENG, Xuanjia , LI, Peng
IPC分类号： A61K31/343
CPC分类号： C07D405/14 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K45/06 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D487/14 , C07D491/048 , C07D498/04
摘要： The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)
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9.发明公开HETEROBICYCLO-SUBSTITUTED-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES 有权HETEROBCYCLOSUBSTITUIERTE [1,2,4]三唑并[1,5-C]喹唑啉-5-胺化合物A2A拮抗性能
公开(公告)号：EP2945632A1
公开(公告)日：2015-11-25
申请号：EP13866588.0
申请日：2013-12-20
发明人： ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , HUANG, Xianhai , HENDERSON, Timothy, J. , KIM, Jae-Hun , BOYCE, Christopher , TING, Pauline , ZHENG, Junying , METZGER, Edward , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda, V. , WON, Walter , WU, Heping , DENG, Qiaolin
IPC分类号： A61K31/4985 , A61K31/519 , C07D487/04 , A61P25/16
CPC分类号： C07D519/00 , C07D487/04
摘要： Disclosed are compounds of Formula Gl (structurally represented): where "RG3" "Rd1" to "Rd4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.
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公开(公告)号：EP3102198B1
公开(公告)日：2020-08-26
申请号：EP15745823.3
申请日：2015-02-03
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