一种真空混合装置或系统中从单体液体和水泥粉末混合聚甲基丙烯酸甲酯骨水泥。 包括至少一个盒用于在所述至少一个盒中，用于接收单独的容器中含有单体的液体或包括容器的内部中的内容混合的骨水泥的混合，混合装置包括可抽真空的内部的设备或系统 含其使得通过移动打开装置布置在所述容器的区域中的方式可相对于所述容器上的开启装置的单体液体，所有一体化的容器，在容器布置在单独的容器是借助于开 开启装置，或者打开装置在集成容器的区域中的方式可相对于一体化的容器布置成使得，通过移动开口装置，所述一体化的容器是可打开的由开口装置的装置，真空泵 在其中可移动的真空柱塞用于产生负压被布置并限定了真空泵的真空泵室，PRESSUR ê泵，其中，用于输送液体的可动柱塞泵布置并限定压力泵，一个连接线，和流体连接的压力泵室。 操作元件还包括做的装置或系统是可操作的从外部worin，通过操作元件的手段，在真空泵的真空柱塞手动是可移动的，在压力泵的泵柱塞手动是可移动的，该开启装置是 可动手动相对于容器或相对于一体化的容器，并且该混合装置是手动可动在盒的内部。

The invention relates to a vacuum mixing apparatus for mixing polymethylmethacrylate bone cement from a monomer and a cement powder (9), the vacuum mixing apparatus comprising at least one cartridge (6) comprising an evacuatable internal space for mixing the bone cement (96), a mixing device (10) for mixing the content of the interior of the at least one cartridge (6) which is movably arranged in the interior, a recess (2) for receiving a the monomer containing separate container (54) or comprising an integrated reservoir containing the monomer, an opening device (5), the in the region of the receptacle (2) against the receptacle (2) is movably arranged so that by movement of the opening means (5) in the receptacle (2) arranged separate container (54) to open with the opening means (5), or the opening means (5) in the region of the integrated container against the in tegrated container is arranged movable, so that by a movement of the opening means (5) of the integrated container with the opening means (5) is open, a vacuum pump (3), in which a movable vacuum envelope (30) for generating a negative pressure is arranged, and of a vacuum pump chamber (94) of the vacuum pump (3) is limited, a pressure pump (3), in which a movable pump piston (31) is arranged for conveying a liquid and a pressure pump chamber (36) of the pressure pump (3) is limited, a connecting line ( 26) which connects the interior of the at least one cartridge (6) (with the vacuum pump chamber 94) of the vacuum pump (3), and a fluid connection (70) connecting the interior of the at least one cartridge (6) (with the pressure pump chamber 36) of the pressure pump (3), wherein the vacuum mixing apparatus having a externally operable operating element (4), with the operating element (4) of the vacuum envelope (30) in the vacuum pump (3), the pump piston (31) in the pressure pump (3), the opening means (5) against the receptacle (2) or against the integrated container and the mixing device (10) in the interior of the cartridge (6) is manually movable. The invention also relates to a method for mixing of PMMA bone cement.