发明公开
EP3181118A1 SYNERGISTIC COMBINATION OF TXNR INHIBITORS AND ASCORBATE FOR TREATMENT OF B CELL MALIGNANCIES
审中-公开
TXNR抑制剂与抗坏血酸的协同处理治疗B细胞恶性肿瘤
- 专利标题： SYNERGISTIC COMBINATION OF TXNR INHIBITORS AND ASCORBATE FOR TREATMENT OF B CELL MALIGNANCIES
- 专利标题（中）： TXNR抑制剂与抗坏血酸的协同处理治疗B细胞恶性肿瘤
-
申请号： EP15461585.0申请日： 2015-12-14
-
公开(公告)号： EP3181118A1公开(公告)日： 2017-06-21
- 发明人: ZAGOZDZON, Radoslaw , FIRCZUK, Malgorzata
- 申请人： Warszawski Uniwersytet Medyczny
- 申请人地址： Ul. Zwirki i Wigury 61 02-091 Warszawa PL
- 专利权人： Warszawski Uniwersytet Medyczny
- 当前专利权人： Warszawski Uniwersytet Medyczny
- 当前专利权人地址： Ul. Zwirki i Wigury 61 02-091 Warszawa PL
- 代理机构： Patpol Kancelaria Patentowa Sp. z o.o.
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K31/375 ; A61K31/66 ; A61K31/7012 ; A61K33/24 ; A61P35/02
摘要：
The present invention relates to a prooxidant synergistic combination to treat B-cell malignancies, such as B cell lymphomas, which comprises a thioredoxin reductase inhibitor, selected from a group comprising auranofin and SK053, and L- or D-ascorbate. The combination of the invention exerts synergistic cytotoxic effects towards malignant, but not normal B cells.
公开/授权文献
信息查询
