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公开(公告)号：EP4408490A1
公开(公告)日：2024-08-07
申请号：EP22793490.8
申请日：2022-09-30
发明人： LEWANDOWSKA-SZUMIE , Malgorzata , SZABLOWSKA-GADOMSKA, Ilona , RUDZINSKI, Stefan , BOCHYNSKA-CZYZ, Marta , GRZELA, Tomasz , MROZIKIEWICZ-RAKOWSKA, Beata
CPC分类号： A61L15/58 , A61L2300/6420130101 , A61L15/34 , A61F13/06
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公开(公告)号：EP3679037B1
公开(公告)日：2023-11-08
申请号：EP18849896.8
申请日：2018-09-04
IPC分类号： C07D417/12 , C07D407/12 , C07D403/12 , C07D257/06 , A61K31/41 , A61K31/427 , A61K31/4196 , A61P31/04 , A61P31/10 , C07D405/12
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公开(公告)号：EP3679037A1
公开(公告)日：2020-07-15
申请号：EP18849896.8
申请日：2018-09-04
IPC分类号： C07D417/12 , C07D407/12 , C07D403/12 , C07D257/06 , A61K31/41 , A61K31/427 , A61K31/4196 , A61P31/04 , A61P31/10
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公开(公告)号：EP3124016B1
公开(公告)日：2019-09-04
申请号：EP15460037.3
申请日：2015-07-31
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公开(公告)号：EP3494955A1
公开(公告)日：2019-06-12
申请号：EP17460074.2
申请日：2017-12-08
IPC分类号： A61K8/36 , A61Q7/00 , A61K31/201 , A61P17/00
摘要： The present invention relates to a composition comprising latanoprost acid. The invention further relates, inter alia, to the use of the composition for preventing or reducing hair loss, and for fortifying hair or promoting hair growth.
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6.发明授权
公开(公告)号：EP3181118B1
公开(公告)日：2019-02-13
申请号：EP15461585.0
申请日：2015-12-14
发明人： ZAGOZDZON, Radoslaw , FIRCZUK, Malgorzata , GRACZYK-JARZYNKA, Agnieszka , TRZECIECKA, Anna , BAJOR, Malgorzata
IPC分类号： A61K9/00 , A61K31/375 , A61K31/66 , A61K31/7012 , A61K33/24 , A61P35/02
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7.发明授权Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound 有权Protoescigenin衍生物，其制备方法，所述化合物的用途以及包含该化合物的药物组合物
公开(公告)号：EP3061765B1
公开(公告)日：2018-01-31
申请号：EP15000566.8
申请日：2015-02-27
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Grynkiewicz, Grzegorz , Gruza, Mariusz Marek , Jatczak, Kamil , Filip, Katarzyna , Cmoch, Piotr , Laszcz, Marta , Dutkiewicz, Malgorzata
CPC分类号： C07J63/008 , A61K31/58
摘要： The present invention relates to a protoescigenin derivative having pharmacological properties, process of its preparation, use of such compound as medicament especially for treating vascular disorders, as well as to a pharmaceutical composition comprising such compound.
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8.发明公开TRANSCRIPTOMIC BIOMARKERS, METHOD FOR DETERMINATION THEREOF AND USE OF TRNASCRIPTOMIC BIOMARKERS FOR INDIVIDUAL RISK ASSESSMENT OF DEVELOPING POST-INFRACTION HEART FAILURE 审中-公开转录生物标记物的方法来确定哪些和心衰的发展评估个体风险转录组生物标记物的使用后梗死
公开(公告)号：EP3105350A2
公开(公告)日：2016-12-21
申请号：EP15712187.2
申请日：2015-02-12
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Warszawski Uniwersytet Medyczny , Uniwersytet Medyczny W Bia Ymstoku
发明人： BURZYNSKA, Beata , GÓRA, Monika , MACIEJAK, Agata , TULACZ, Dorota , KILISZEK, Marek , MICHALAK, Marcin , OPOLSKI, Grzegorz , MATLAK, Krzysztof , DOBRZYCKI, Slawomir
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates to biomarkers for individual risk assessment of the development of post-infarction heart failure, the method of determining the markers in samples of biological material collected from a patient. Further, the invention relates to a use of the biomarkers in the diagnosis (expression level of the gene) that correlate with the developing post-infarction heart failure, and enable prevention of heart disease based on a genetic marker and a method for predicting the risk of developing a heart failure for post-infarction patients. Also a method for optimizing the treatment of cardiac patients with the use of the means of the invention is disclosed.
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9.发明公开HORSE CHESTNUT EXTRACT OR ESCINS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开EXTRAKT VONGEWÖHNLICHERROSSKASTANIE ODER AESCINS ZUR BEHANDLUNG冯ALZHEIMER-KRANKHEIT
公开(公告)号：EP3078381A1
公开(公告)日：2016-10-12
申请号：EP15001035.3
申请日：2015-04-10
申请人： Warszawski Uniwersytet Medyczny , INSTYTUT FARMACEUTYCZNY , Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
发明人： Koziak, Katarzyna , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Domanski, Dominik , Perzanowska, Anna
CPC分类号： A61K36/77
摘要： The subject invention relates to agents for use in treatment and/or prevention of Alzheimer's disease. The group of agents include horse chestnut extract, escins, their salts and derivatives.
摘要翻译： 本发明涉及用于治疗和/或预防阿尔茨海默病的药剂。 该组代理包括马蹄提取物，海鞘，其盐和衍生物。
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10.发明公开PROCESS FOR PREPARATION OF 3,24;16,22-DI-O,O-ISOPROPYLIDENEPROTOESCIGENIN AND CRYSTALLINE FORMS THEREOF 审中-公开制备3,24; 16,22-DI-O，O-异丙基对苯二酚硒的方法及其结晶形式
公开(公告)号：EP2945961A1
公开(公告)日：2015-11-25
申请号：EP13828891.5
申请日：2013-12-30
发明人： GRUZA, Mariusz , JATCZAK, Kamil , LASZCZ, Marta , GRYNKIEWICZ, Grzegorz , GILLER, Tomasz , WITKOWSKA, Anna
CPC分类号： C07J63/008 , C07J71/0026
摘要： Process for preparation of 3,24;16,22-di-O,O-isopropylideneprotoescigenin comprises acetonidation of protoescigenin monohydrate in the mixture consisting of 0 - 100% vol. of acetone and 100 - 0% vol. of 2,2-dimethoxypropane, in presence of catalytic amount of an acid, furnishing precipitation of the crystalline product from the reaction mixture. 3,24; 16,22 -Di-O,O- isopropylideneprotoescigenin is isolated either in crystalline form A or B.
摘要翻译： 用于制备3,24; 16,22-二-O，O-异亚丙基原豆蔻醌的方法包括在由0-100％体积的组合物组成的混合物中对原水杨醇凝胶素一水合物进行乙酰化。 丙酮和100-0％体积。 的2,2-二甲氧基丙烷在催化量的酸存在下提供结晶产物从反应混合物中沉淀出来。 3,24; 以结晶形式A或B分离16,22-Di-O，O-异亚丙基原古菌素。
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