发明公开
EP3199554A1 ANTIBODY CAPABLE OF NEUTRALIZING SUBSTANCE HAVING ACTIVITY ALTERNATIVE TO FUNCTION OF COAGULATION FACTOR VIII (FVIII)
审中-公开
能够具有凝血因子VIII功能活性的中和物质的抗体（FVIII）
- 专利标题： ANTIBODY CAPABLE OF NEUTRALIZING SUBSTANCE HAVING ACTIVITY ALTERNATIVE TO FUNCTION OF COAGULATION FACTOR VIII (FVIII)
- 专利标题（中）： 能够具有凝血因子VIII功能活性的中和物质的抗体（FVIII）
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申请号： EP15843808.5申请日： 2015-09-24
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公开(公告)号： EP3199554A1公开(公告)日： 2017-08-02
- 发明人: IGAWA, Tomoyuki , MUTO, Atsushi , KITAZAWA, Takehisa , SUZUKI, Tsukasa
- 申请人： Chugai Seiyaku Kabushiki Kaisha
- 申请人地址： 5-1, Ukima 5-chome Kita-ku Tokyo 115-8543 JP
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： 5-1, Ukima 5-chome Kita-ku Tokyo 115-8543 JP
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： JP2014197207 20140926
- 国际公布： WO2016047656 20160331
- 主分类号： C07K16/42
- IPC分类号： C07K16/42 ; C07K16/36 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/09 ; C12P21/08
摘要：
The present inventors attempted to produce antibodies that neutralize the activity of a substance having an activity of functionally substituting for FVIII to be used for the method of measuring the reactivity of FVIII in the presence of a substance having an activity of functionally substituting for FVIII. As a result, the inventors discovered that by using the produced antibodies, FVIII activity in the plasma of a hemophilia A patient can be evaluated accurately by one-stage clotting assay based on APTT, and also that FVIII inhibitor titer in the plasma of a hemophilia A patient carrying a FVIII inhibitor can be evaluated accurately by Bethesda assay based on APTT.
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