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1.发明公开ANTIBODY CAPABLE OF NEUTRALIZING SUBSTANCE HAVING ACTIVITY ALTERNATIVE TO FUNCTION OF COAGULATION FACTOR VIII (FVIII) 审中-公开能够具有凝血因子VIII功能活性的中和物质的抗体（FVIII）
公开(公告)号：EP3199554A1
公开(公告)日：2017-08-02
申请号：EP15843808.5
申请日：2015-09-24
摘要： The present inventors attempted to produce antibodies that neutralize the activity of a substance having an activity of functionally substituting for FVIII to be used for the method of measuring the reactivity of FVIII in the presence of a substance having an activity of functionally substituting for FVIII. As a result, the inventors discovered that by using the produced antibodies, FVIII activity in the plasma of a hemophilia A patient can be evaluated accurately by one-stage clotting assay based on APTT, and also that FVIII inhibitor titer in the plasma of a hemophilia A patient carrying a FVIII inhibitor can be evaluated accurately by Bethesda assay based on APTT.
摘要翻译： 本发明人试图制备中和具有功能性取代FVIII活性的物质的活性的抗体，用于在具有功能性替代FVIII活性的物质存在下测量FVIII反应性的方法。 结果，发明人发现通过使用所产生的抗体，可以通过基于APTT的一阶段凝血测定法准确评估A型血友病患者血浆中的FVIII活性，并且还可以确定血友病血浆中的FVIII抑制剂效价 携带FVIII抑制剂的患者可以通过基于APTT的Bethesda测定法进行准确评估。
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2.发明授权MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 有权具有选择性功能的多特异性抗原结合分子对血液凝固因子VIII的作用
公开(公告)号：EP2644698B1
公开(公告)日：2018-01-03
申请号：EP11842145.2
申请日：2011-11-17
发明人： IGAWA, Tomoyuki , SAMPEI, Zenjiro , KOJIMA, Tetsuo , SOEDA, Tetsuhiro , MUTO, Atsushi , KITAZAWA, Takehisa , NISHIDA, Yukiko , IMAI, Chifumi , SUZUKI, Tsukasa , YOSHIHASHI, Kazutaka
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
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3.发明公开MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 有权与血液凝血因子VIII功能改变多特异性抗原结合分子
公开(公告)号：EP2644698A1
公开(公告)日：2013-10-02
申请号：EP11842145.2
申请日：2011-11-17
发明人： IGAWA, Tomoyuki , SAMPEI, Zenjiro , KOJIMA, Tetsuo , SOEDA, Tetsuhiro , MUTO, Atsushi , KITAZAWA, Takehisa , NISHIDA, Yukiko , IMAI, Chifumi , SUZUKI, Tsukasa , YOSHIHASHI, Kazutaka
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
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4.发明公开MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 审中-公开具有选择性功能的多特异性抗原结合分子对血液凝固因子VIII的作用
公开(公告)号：EP3318633A1
公开(公告)日：2018-05-09
申请号：EP17200495.4
申请日：2011-11-17
发明人： IGAWA, Tomoyuki , SAMPEI, Zenjiro , KOJIMA, Tetsuo , SOEDA, Tetsuhiro , MUTO, Atsushi , KITAZAWA, Takehisa , NISHIDA, Yukiko , IMAI, Chifumi , SUZUKI, Tsukasa , YOSHIHASHI, Kazutaka
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译： 与血液凝固因子IX /激活的凝血因子IX和血液凝固因子X特异性结合并且在功能上取代凝血因子VIII的辅因子功能的各种双特异性抗体，即通过以下方式促进血液凝固因子X活化的功能： 产生活化的凝血因子IX。 从这些抗体中成功发现了功能性取代凝血因子VIII的多特异性抗原结合分子。
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公开(公告)号：EP3047857A1
公开(公告)日：2016-07-27
申请号：EP14845545.4
申请日：2014-09-19
IPC分类号： A61K39/395 , A61K45/00 , A61P7/04 , C07K16/18
CPC分类号： C07K16/40 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/76 , A61K2300/00
摘要： The present inventors have completed the present invention by finding that an excellent anticoagulation inhibitory effect is obtained by the administration of an agent inhibiting the activation of protein C.
摘要翻译： 本发明人通过发现通过施用抑制蛋白质C的活化的试剂获得优异的抗凝抑制效果，完成了本发明。
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