发明公开
EP3200792A2 POLY (ADP-RIBOSE) POLYMERASE 1 INHIBITORS STRUCTURALLY UNRELATED TO NAD
审中-公开
POLY（ADP-RIBOSE）聚合酶1抑制剂结构上与NAD无关
- 专利标题： POLY (ADP-RIBOSE) POLYMERASE 1 INHIBITORS STRUCTURALLY UNRELATED TO NAD
- 专利标题（中）： POLY（ADP-RIBOSE）聚合酶1抑制剂结构上与NAD无关
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申请号： EP15847892.5申请日： 2015-09-30
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公开(公告)号： EP3200792A2公开(公告)日： 2017-08-09
- 发明人: TULIN, Alexei
- 申请人： The Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
- 申请人地址： 333 Cottman Avenue Philadelphia, PA 19111 US
- 专利权人： The Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
- 当前专利权人： The Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
- 当前专利权人地址： 333 Cottman Avenue Philadelphia, PA 19111 US
- 代理机构： Ghirardi, Valeria
- 优先权： US201462059201P 20141003
- 国际公布： WO2016054237 20160407
- 主分类号： A61K31/4453
- IPC分类号： A61K31/4453 ; A61P35/00 ; C07D211/14
摘要：
Compounds that are not related to NAD, and which target PARP1-histone H4 interaction are provided, as well as compositions of these compounds, and methods for specific inhibition of poly(ADP-ribose) polymerase 1 (PARP-1) using these compounds are provided. These PARP-1 inhibitors may be used to treat cancer in which PARP-1 activation or biologic activity plays a role, including prostate cancer, breast cancer, kidney cancer, ovarian cancer, lymphoma, leukemia, and glioblastoma, among others.
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