发明公开
EP3224354A1 ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
审中-公开
用于酮和胺化合物的还原胺化的工程化亚胺减少物和方法
- 专利标题： ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
- 专利标题（中）： 用于酮和胺化合物的还原胺化的工程化亚胺减少物和方法
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申请号： EP15864252.0申请日： 2015-11-24
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公开(公告)号： EP3224354A1公开(公告)日： 2017-10-04
- 发明人: ALVIZO, Oscar , MAYO, Melissa Ann , MOORE, Jeffrey C.
- 申请人： Codexis, Inc.
- 申请人地址： 200 Penobscot Drive Redwood City, CA 94063 US
- 专利权人： Codexis, Inc.
- 当前专利权人： Codexis, Inc.
- 当前专利权人地址： 200 Penobscot Drive Redwood City, CA 94063 US
- 代理机构： Chapman, Desmond Mark
- 优先权： US201462084037P 20141125
- 国际公布： WO2016085916 20160602
- 主分类号： C12N9/08
- IPC分类号： C12N9/08
摘要：
The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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