公开(公告)号：EP2847327B1

公开(公告)日：2018-12-26

申请号：EP13788385.6

申请日：2013-05-07

申请人： Codexis, Inc.

发明人： CHEN, Haibin ,  BONG, Yong Koy ,  CABIROL, Fabien ,  GOHEL, Anupam ,  LI, Tao ,  MOORE, Jeffrey C. ,  QUINTANAR-AUDELO, Martina ,  YANG, Hong ,  COLLIER, Steven, J. ,  SMITH, Derek

IPC分类号： C12N9/04 ,  C12N5/00 ,  C12P17/18 ,  C12N9/02 ,  C12P13/04 ,  C12P13/24 ,  C12P17/12

CPC分类号： C12P17/12 ,  C12N9/0071 ,  C12P13/04 ,  C12P13/24 ,  C12P17/188 ,  C12Y114/11002 ,  Y02P20/52

摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts, methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts.

公开(公告)号：EP2946006B1

公开(公告)日：2019-04-10

申请号：EP14740809.0

申请日：2014-01-16

申请人： Codexis, Inc.

发明人： SUKUMARAN, Joly ,  SMITH, Derek ,  YANG, Hong ,  YEO, Wan Lin ,  MOORE, Jeffrey C.

IPC分类号： C12N9/18 ,  C12P17/18

公开(公告)号：EP2847327A2

公开(公告)日：2015-03-18

申请号：EP13788385.6

申请日：2013-05-07

申请人： Codexis, Inc.

发明人： CHEN, Haibin ,  BONG, Yong Koy ,  CABIROL, Fabien ,  GOHEL, Anupam ,  LI, Tao ,  MOORE, Jeffrey C. ,  QUINTANAR-AUDELO, Martina ,  YANG, Hong ,  COLLIER, Steven, J. ,  SMITH, Derek

IPC分类号： C12N9/04

CPC分类号： C12P17/12 ,  C12N9/0071 ,  C12P13/04 ,  C12P13/24 ,  C12P17/188 ,  C12Y114/11002 ,  Y02P20/52

摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts, methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts.

摘要翻译： 本公开内容提供了用于产生羟基化化合物的工程化脯氨酸羟化酶多肽，编码工程化脯氨酸羟化酶的多核苷酸，能够表达工程化脯氨酸羟化酶的宿主细胞，以及使用工程化脯氨酸羟化酶制备可用于生产活性药物的化合物的方法 代理商。

公开(公告)号：EP3224354A1

公开(公告)日：2017-10-04

申请号：EP15864252.0

申请日：2015-11-24

申请人： Codexis, Inc.

发明人： ALVIZO, Oscar ,  MAYO, Melissa Ann ,  MOORE, Jeffrey C.

IPC分类号： C12N9/08

CPC分类号： C12N9/0028 ,  C07K14/195 ,  C12P13/001

摘要： The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

摘要翻译： 本申请提供了具有亚胺还原酶活性的工程化多肽，编码工程化亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞以及使用这些工程化多肽与一系列酮和胺底物化合物制备仲胺和叔胺的方法 产品化合物。

公开(公告)号：EP3068793A1

公开(公告)日：2016-09-21

申请号：EP14862555.1

申请日：2014-11-12

申请人： Codexis, Inc.

发明人： AGARD, Nicholas J. ,  ALVIZO, Oscar ,  MAYO, Melissa Ann ,  NG MINOR, Stefanie ,  RIGGINS, James Nicholas ,  MOORE, Jeffrey C.

IPC分类号： C07K14/305

CPC分类号： C12N9/0028 ,  C12P13/001 ,  C12P17/10 ,  C12Y105/01028

摘要： The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

摘要翻译： 本申请提供具有亚胺还原酶活性的工程化多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。