Invention Publication
- Patent Title: NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
- Patent Title (中): 新型三环化合物作为突变IDH酶的抑制剂
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Application No.: EP15865691.8Application Date: 2015-12-01
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Publication No.: EP3226688A1Publication Date: 2017-10-11
- Inventor: FISCHER, Christian , BOGEN, Stephane, L. , CHILDERS, Matthew, L. , LLINAS, Francesc Xavier Fradera , ELLIS, J. Michael , ESPOSITE, Sara , HONG, Qingmei , HUANG, Chunhui , KIM, Alexander, J. , LAMPE, John, W. , MACHACEK, Michelle, R. , MCMASTERS, Daniel, R. , OTTE, Ryan, D. , PARKER, Dann, L., Jr. , REUTERSHAN, Michael , SCIAMMETTA, Nunzio , SHAO, Pengcheng, P. , SLOMAN, David, L. , UJJAINWALLA, Feroze , WHITE,Catherine , WU, Zhicai
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- Agency: Böhles, Elena
- Priority: US201462088262P 20141205
- International Announcement: WO2016089797 20160609
- Main IPC: A01N43/00
- IPC: A01N43/00
Abstract:
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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