发明公开
- 专利标题： NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
- 专利标题（中）： 新型三环化合物作为突变IDH酶的抑制剂
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申请号： EP15866280.9申请日： 2015-12-01
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公开(公告)号： EP3226690A1公开(公告)日： 2017-10-11
- 发明人: FISCHER, Christian , BOGEN, Stephane, L. , CHILDERS, Matthew, L. , LLINAS, Francesc Xavier Fradera , KIM, Alexander, J. , LAMPE, John, W. , MACHACEK, Michelle, R. , MCMASTERS, Daniel, R. , PARKER, Dann, L., Jr. , SUN, Wanying , SCIAMMETTA, Nunzio , SHAO, Pengcheng, P. , SLOMAN, David, L. , UJJAINWALLA, Feroze , HUANG, Chunhui
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Böhles, Elena
- 优先权： US201462088274P 20141205
- 国际公布： WO2016089833 20160609
- 主分类号： A01N43/00
- IPC分类号： A01N43/00
摘要：
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), (II-ii), (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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