发明公开
- 专利标题: END CAPPED NUCLEIC ACID MOLECULES
- 专利标题(中): 封端的核酸分子
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申请号: EP15823199.3申请日: 2015-12-16
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公开(公告)号: EP3233880A1公开(公告)日: 2017-10-25
- 发明人: BARNES-SEEMAN, David , COHEN, Scott Louis , DIENER, John Louis , GAMPE, Christian , ROACHE, James , WHITE, Amy , WILLIAMS, Sarah , YUAN, Jun , ZECRI, Frederic
- 申请人: Novartis AG
- 申请人地址: Lichtstrasse 35 4056 Basel CH
- 专利权人: Novartis AG
- 当前专利权人: Novartis AG
- 当前专利权人地址: Lichtstrasse 35 4056 Basel CH
- 代理机构: Campbell, Lachlan Clive
- 优先权: US201462092627P 20141216
- 国际公布: WO2016098028 20160623
- 主分类号: C07H19/167
- IPC分类号: C07H19/167 ; C07H21/02 ; C07F9/38
摘要:
The disclosure relates to nucleic acids that contain modifications at the 5′-end, 3′-end or 5′-end and 3′-ends, and compounds that can be used to make the modified nucleic acids arc disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.
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