公开(公告)号：EP3904366A1

公开(公告)日：2021-11-03

申请号：EP20197788.1

申请日：2015-12-16

申请人： Novartis AG

发明人： BARNES-SEEMAN, David ,  COHEN, Scott Louis ,  DIENER, John Louis ,  GAMPE, Christian ,  ROACHE, James ,  WHITE, Amy ,  WILLIAMS, Sarah ,  YUAN, Jun ,  ZECRI, Frederic

IPC分类号： C07H19/167 ,  C07H21/02 ,  C07F9/38 ,  C07F9/6561 ,  C07H19/207

摘要： The disclosure relates to nucleic acids that contain modifications at the 5'-end, 3'-end or 5'-end and 3'-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.The compounds are of formula (I)

公开(公告)号：EP3233880A1

公开(公告)日：2017-10-25

申请号：EP15823199.3

申请日：2015-12-16

申请人： Novartis AG

发明人： BARNES-SEEMAN, David ,  COHEN, Scott Louis ,  DIENER, John Louis ,  GAMPE, Christian ,  ROACHE, James ,  WHITE, Amy ,  WILLIAMS, Sarah ,  YUAN, Jun ,  ZECRI, Frederic

IPC分类号： C07H19/167 ,  C07H21/02 ,  C07F9/38

CPC分类号： C07H21/02 ,  C07F9/65616 ,  C07H19/167 ,  C07H19/207 ,  C07K14/5759

摘要： The disclosure relates to nucleic acids that contain modifications at the 5′-end, 3′-end or 5′-end and 3′-ends, and compounds that can be used to make the modified nucleic acids arc disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

摘要翻译： 本公开涉及在5'-末端，3'-末端或5'-末端和3'-末端含有修饰的核酸，并且公开了可用于制备修饰的核酸的化合物。 与未修饰的核酸相比，修饰的核酸具有改善的表达，较低的免疫原性和改善的稳定性。