发明公开
- 专利标题： STEM CELLS FOR MODELING TYPE 2 DIABETES
- 专利标题（中）： 干细胞用于建模2型糖尿病
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申请号： EP15820988.2申请日： 2015-12-18
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公开(公告)号： EP3234111A1公开(公告)日： 2017-10-25
- 发明人: GONG, Guochun , LAI, Ka-Man Venus , VALENZUELA, David M.
- 申请人： Regeneron Pharmaceuticals, Inc.
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 代理机构： Hutter, Anton
- 优先权： US201462094868P 20141219
- 国际公布： WO2016100857 20160623
- 主分类号： C12N5/074
- IPC分类号： C12N5/074 ; C12N15/10 ; C12N15/113 ; A61K35/39 ; A61K35/12 ; A61K35/545 ; C12N5/071 ; C12N15/63 ; C12N15/90
摘要：
The invention provides stem cell derived beta-pancreatic cells and animal models of T2D in which cells have been grafted. The stem cells bear a mutated form of SLC30A8 conferring protection or susceptibility to T2D. The cells and animal models can be used for drug screening as well as to provide insights into the mechanism of T2D and potentially new therapeutic and diagnostic targets.
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