发明公开
EP3243826A1 IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION
审中-公开
作为蛋白酶激活的受体4（PAR4）抑制剂治疗血小板聚集的咪唑并二氮杂和咪唑并吡嗪衍生物
- 专利标题： IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION
- 专利标题（中）： 作为蛋白酶激活的受体4（PAR4）抑制剂治疗血小板聚集的咪唑并二氮杂和咪唑并吡嗪衍生物
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申请号： EP17172927.0申请日： 2013-04-24
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公开(公告)号： EP3243826A1公开(公告)日： 2017-11-15
- 发明人: BANVILLE, Jacques , RÉMILLARD, Roger , RUEDIGER, Edward H. , DEON, Daniel H. , GAGNON, Marc , DUBÉ, Laurence , GUY, Julia , PRIESTLEY, Eldon Scott , POSY, Shoshana L. , MAXWELL, Brad D. , WONG, Pancras C. , LAWRENCE, Michael R. , MILLER, Michael M.
- 申请人： Bristol-Myers Squibb Company , The Universite de Montreal
- 申请人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 专利权人： Bristol-Myers Squibb Company,The Universite de Montreal
- 当前专利权人： Bristol-Myers Squibb Company,The Universite de Montreal
- 当前专利权人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 代理机构： Beacham, Annabel Rose
- 优先权： US201261638577P 20120426; US201361787680P 20130315
- 主分类号： C07D519/00
- IPC分类号： C07D519/00 ; A61K31/433 ; C07D513/04 ; A61K31/5025 ; C07D487/04 ; A61K31/4355 ; A61P7/02
摘要：
The present invention provides thiazole compounds of Formula I
wherein W, Y, R 0 , R 2 , R 4 , R 5 , R 6 , R 7 , X 1 , X 2 , X 3 and X 4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
wherein W, Y, R 0 , R 2 , R 4 , R 5 , R 6 , R 7 , X 1 , X 2 , X 3 and X 4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
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