发明公开
EP3254681A1 N-(5S,6S,9R)-5-AMINO-6-(2,3-DIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[B]PYRIDIN-9-YL-4-(2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-1-YL)PIPERIDINE-1-CARBOXYLATE SALT
审中-公开
N-（5S，6S，9R）-5-氨基-6-（2,3-二氟苯基）-6,7,8,9-四氢-5H-环庚并[b]吡啶-9-基-4-（2- - 氧代-2,3-二氢-1H-咪唑并[4,5-b]吡啶-1-基）哌啶-1-羧酸酯盐
- 专利标题： N-(5S,6S,9R)-5-AMINO-6-(2,3-DIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[B]PYRIDIN-9-YL-4-(2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-1-YL)PIPERIDINE-1-CARBOXYLATE SALT
- 专利标题（中）： N-（5S，6S，9R）-5-氨基-6-（2,3-二氟苯基）-6,7,8,9-四氢-5H-环庚并[b]吡啶-9-基-4-（2- - 氧代-2,3-二氢-1H-咪唑并[4,5-b]吡啶-1-基）哌啶-1-羧酸酯盐
-
申请号： EP17180587.2申请日： 2013-02-25
-
公开(公告)号： EP3254681A1公开(公告)日： 2017-12-13
- 发明人: ROBERTS, Daniel Richard , SCHARTMAN, Richard Raymond , WEI, Chenkou
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 代理机构： Reitstötter Kinzebach
- 优先权： US201261603598P 20120227
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; C07D471/04 ; A61P11/00 ; A61P25/00
摘要：
Disclosed is a hemisulfate salt of Compound (I): and crystalline forms of the hemisulfate salt. Also disclosed are methods of using the hemisulfate salt of Compound (1) as a CGRP receptor antagonist, and pharmaceutical compositions comprising the hemisulfate salt of Compound (I). The hemisulfate salt of Compound (I) is useful in treating, preventing, or ameliorating disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).
公开/授权文献
信息查询
IPC分类:
