发明公开
- 专利标题： KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE
- 专利标题（中）： KDM1A用于治疗疾病的抑制剂
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申请号： EP16749986.2申请日： 2016-02-12
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公开(公告)号： EP3256218A1公开(公告)日： 2017-12-20
- 发明人: RIENHOFF, Hugh, Young, Jr. , MCCALL, John, M. , CLARE, Michael , CELATKA, Cassandra , TAPPER, Amy, E.
- 申请人： Imago Biosciences Inc.
- 申请人地址： 2729 Debbie Court San Carlos, CA 94070 US
- 专利权人： Imago Biosciences Inc.
- 当前专利权人： Imago Biosciences Inc.
- 当前专利权人地址： 2729 Debbie Court San Carlos, CA 94070 US
- 代理机构： Boult Wade Tennant
- 优先权： US201562115474P 20150212
- 国际公布： WO2016130952 20160818
- 主分类号： A61P35/02
- IPC分类号： A61P35/02 ; C07C237/22 ; C07C211/35
摘要：
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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