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公开(公告)号：EP3790867A1
公开(公告)日：2021-03-17
申请号：EP19800758.5
申请日：2019-05-13
IPC分类号： C07D241/18 , C07D403/04 , C07D403/10 , C07D403/14 , C07D491/107
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公开(公告)号：EP3256218A1
公开(公告)日：2017-12-20
申请号：EP16749986.2
申请日：2016-02-12
发明人： RIENHOFF, Hugh, Young, Jr. , MCCALL, John, M. , CLARE, Michael , CELATKA, Cassandra , TAPPER, Amy, E.
IPC分类号： A61P35/02 , C07C237/22 , C07C211/35
CPC分类号： C07D249/06 , A61K9/0053 , A61K9/1623 , A61K9/4858 , A61K31/397 , A61K31/41 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/551 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C53/18 , C07C309/30 , C07D205/04 , C07D211/66 , C07D215/54 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/42 , C07D249/08 , C07D263/32 , C07D279/12 , C07D295/192 , C07D295/26 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , A61K2300/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：EP4419504A1
公开(公告)日：2024-08-28
申请号：EP22884605.1
申请日：2022-10-17
IPC分类号： C07D231/38 , A61P35/02 , A61K31/415
CPC分类号： C07D231/38 , A61P35/02 , C07D401/12 , C07D403/04 , C07D403/12 , C07D401/14 , C07D401/04 , C07D403/10 , C07D403/14 , C07D401/10 , C07D453/02 , C07D519/00 , C07D495/08 , C07D413/12 , C07D491/107 , C07D413/04 , C07D405/12 , A61K45/06 , A61K31/454
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公开(公告)号：EP4221704A1
公开(公告)日：2023-08-09
申请号：EP21876583.2
申请日：2021-10-01
IPC分类号： A61K31/397 , A61K31/41 , A61K31/4162
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