发明公开
- 专利标题: SOLVATED FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
- 专利标题(中): 溶解形式的突触酪氨酸激酶抑制剂
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申请号: EP16773859.0申请日: 2016-03-25
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公开(公告)号: EP3273961A1公开(公告)日: 2018-01-31
- 发明人: GOLDMAN, Erick , SMYTH, Mark Stephen , BONNAUD, Thierry , MUNOZ GARCIA, Alberto , WORRALL, Christopher Peter
- 申请人: Pharmacyclics LLC
- 申请人地址: 995 East Arques Avenue Sunnyvale, CA 94085 US
- 专利权人: Pharmacyclics LLC
- 当前专利权人: Pharmacyclics LLC
- 当前专利权人地址: 995 East Arques Avenue Sunnyvale, CA 94085 US
- 代理机构: Miller, David James
- 优先权: US201562139594P 20150327
- 国际公布: WO2016160598 20161006
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; A61P35/00 ; C07D487/04
摘要:
Described herein are solvates of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the solvates, as well as methods of using the solvates, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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