公开(公告)号：EP3273962A1

公开(公告)日：2018-01-31

申请号：EP16773865.7

申请日：2016-03-25

申请人： Pharmacyclics LLC

发明人： GOLDMAN, Erick ,  SMYTH, Mark Stephen ,  BONNAUD, Thierry ,  SULEIMAN, Osama ,  WORRALL, Christopher Peter

IPC分类号： A61K31/519 ,  A61P35/00 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K9/145 ,  A61K31/519 ,  G01N23/20075

摘要： Disclosed are co-crystals of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the co-crystals, as well as methods of using co-crystals, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：EP3273961A1

公开(公告)日：2018-01-31

申请号：EP16773859.0

申请日：2016-03-25

申请人： Pharmacyclics LLC

发明人： GOLDMAN, Erick ,  SMYTH, Mark Stephen ,  BONNAUD, Thierry ,  MUNOZ GARCIA, Alberto ,  WORRALL, Christopher Peter

IPC分类号： A61K31/519 ,  A61P35/00 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  G01N23/20075

摘要： Described herein are solvates of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the solvates, as well as methods of using the solvates, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.