发明公开
EP3283486A1 MALEATE SALTS OF A B-RAF KINASE INHIBITOR, CRYSTALLINE FORMS, METHODS OF PREPARATION, AND USES THEREFORE
审中-公开
B-RAF激酶抑制剂的锰盐，结晶形式，制备方法及其用途
- 专利标题： MALEATE SALTS OF A B-RAF KINASE INHIBITOR, CRYSTALLINE FORMS, METHODS OF PREPARATION, AND USES THEREFORE
- 专利标题（中）： B-RAF激酶抑制剂的锰盐，结晶形式，制备方法及其用途
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申请号： EP16779601.0申请日： 2016-04-14
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公开(公告)号： EP3283486A1公开(公告)日： 2018-02-21
- 发明人: ZHANG, Guoliang , ZHOU, Changyou
- 申请人： BeiGene, Ltd.
- 申请人地址： c/o Mourant Ozannes Corporate Services (Cayman) Limited 94 Solaris Avenue, PO Box 1348 George Town, KY1-1108 Camana Bay Grand Cayman KY
- 专利权人： BeiGene, Ltd.
- 当前专利权人： BeiGene, Ltd.
- 当前专利权人地址： c/o Mourant Ozannes Corporate Services (Cayman) Limited 94 Solaris Avenue, PO Box 1348 George Town, KY1-1108 Camana Bay Grand Cayman KY
- 代理机构： Kremer, Simon Mark
- 优先权： PCT/CN2015/076639 20150415
- 国际公布： WO2016165626 20161020
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; C07D471/04 ; A61K31/4184 ; A61K31/4355 ; A61K31/5585 ; A61P35/00
摘要：
The invention relates to 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo [d] imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa [b] benzofuran-5-yl) oxy)-3,4-dihydro-1,8-naphthyridin-2 (1H)-one (Compound 1) maleate salts, in particular the sesqui-maleate salt and its crystalline forms, methods of preparation, pharmaceutical compositions, and therapeutic uses for treatment of diseases or disorders mediated by BRAF or other kinases.
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