发明公开
EP3296289A2 PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
审中-公开
苯基取代的环烷基胺作为单胺再利用抑制剂
- 专利标题： PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
- 专利标题（中）： 苯基取代的环烷基胺作为单胺再利用抑制剂
-
申请号： EP17178036.4申请日： 2008-06-02
-
公开(公告)号： EP3296289A2公开(公告)日： 2018-03-21
- 发明人: SHAO, Liming , WANG, Fengjiang , MALCOLM, Scott, Christopher , HEWITT, Michael, Charles , MA, Jianguo , VARNEY, Mark, A , CAMPBELL, Una , ENGEL, Sharon, Rae , HARDY, Larry, Wendell , KOCH, Patrick , SCHREIBER, Rudy , SPEAR, Kerry, L
- 申请人： Sunovion Pharmaceuticals Inc.
- 申请人地址： 84 Waterford Drive Marlborough, MA 01752-7010 US
- 专利权人： Sunovion Pharmaceuticals Inc.
- 当前专利权人： Sunovion Pharmaceuticals Inc.
- 当前专利权人地址： 84 Waterford Drive Marlborough, MA 01752-7010 US
- 代理机构： HGF Limited
- 优先权： US941242P 20070531
- 主分类号： C07C215/42
- IPC分类号： C07C215/42 ; C07C217/52 ; A61P25/24 ; A61P25/28 ; A61K31/135
摘要：
Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
公开/授权文献
信息查询
