公开(公告)号：EP1976513B1

公开(公告)日：2016-08-24

申请号：EP07716419.2

申请日：2007-01-05

申请人： Sunovion Pharmaceuticals Inc.

发明人： SHAO, Liming ,  WANG, Fengjiang ,  MALCOLM, Scott, Christopher ,  HEWITT, Michael, Charles ,  BUSH, Larry, R. ,  MA, Jianguo ,  VARNEY, Mark, A. ,  CAMPBELL, Una ,  ENGEL, Sharon, Rae ,  HARDY, Larry, Wendell ,  KOCH, Patrick ,  CAMPBELL, John, E.

IPC分类号： A61K31/381 ,  A61K31/335

CPC分类号： C07D333/20 ,  C07C211/17 ,  C07C211/29 ,  C07C211/40 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D211/16 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056

摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

公开(公告)号：EP1978961B1

公开(公告)日：2016-03-16

申请号：EP06848050.8

申请日：2006-12-21

申请人： Sunovion Pharmaceuticals Inc.

发明人： SHAO, Liming ,  WANG, Fengjiang ,  MALCOLM, Scott, Christopher ,  HEWITT, Michael, Charles ,  BUSH, Larry, R. ,  VARNEY, Mark ,  CAMPBELL, Una ,  ENGEL, Sharon, Rae ,  HARDY, Larry, Wendell ,  KOCH, Patrick ,  MA, Jianguo

IPC分类号： C07D215/12 ,  C07C211/30 ,  C07C211/40 ,  C07C215/44 ,  C07C217/74 ,  A01N43/42 ,  A61K31/47

CPC分类号： C07C211/40 ,  C07C17/16 ,  C07C17/35 ,  C07C45/38 ,  C07C45/52 ,  C07C45/63 ,  C07C45/67 ,  C07C45/68 ,  C07C45/74 ,  C07C211/29 ,  C07C211/30 ,  C07C211/42 ,  C07C215/44 ,  C07C217/74 ,  C07C2601/14 ,  C07C2602/10 ,  C07D215/12 ,  C07C25/22 ,  C07C22/04 ,  C07C47/453 ,  C07C49/67 ,  C07C49/697 ,  C07C49/255 ,  C07C49/755 ,  C07C49/683

公开(公告)号：EP3296289A3

公开(公告)日：2018-06-20

申请号：EP17178036.4

申请日：2008-06-02

申请人： Sunovion Pharmaceuticals Inc.

发明人： SHAO, Liming ,  WANG, Fengjiang ,  MALCOLM, Scott, Christopher ,  HEWITT, Michael, Charles ,  MA, Jianguo ,  VARNEY, Mark, A ,  CAMPBELL, Una ,  ENGEL, Sharon, Rae ,  HARDY, Larry, Wendell ,  KOCH, Patrick ,  SCHREIBER, Rudy ,  SPEAR, Kerry, L

IPC分类号： C07C215/42 ,  C07C217/52 ,  A61P25/24 ,  A61P25/28 ,  A61K31/135

CPC分类号： C07C215/42 ,  A61K31/135 ,  A61P25/24 ,  A61P25/28 ,  C07B2200/07 ,  C07C217/52 ,  C07C217/76 ,  C07C2601/14

摘要： Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

公开(公告)号：EP3296289A2

公开(公告)日：2018-03-21

申请号：EP17178036.4

申请日：2008-06-02

申请人： Sunovion Pharmaceuticals Inc.

发明人： SHAO, Liming ,  WANG, Fengjiang ,  MALCOLM, Scott, Christopher ,  HEWITT, Michael, Charles ,  MA, Jianguo ,  VARNEY, Mark, A ,  CAMPBELL, Una ,  ENGEL, Sharon, Rae ,  HARDY, Larry, Wendell ,  KOCH, Patrick ,  SCHREIBER, Rudy ,  SPEAR, Kerry, L

IPC分类号： C07C215/42 ,  C07C217/52 ,  A61P25/24 ,  A61P25/28 ,  A61K31/135

CPC分类号： C07C215/42 ,  A61K31/135 ,  A61P25/24 ,  A61P25/28 ,  C07B2200/07 ,  C07C217/52 ,  C07C217/76 ,  C07C2601/14

摘要： Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

摘要翻译： 公开了苯基取代的环己胺衍生物及其合成和表征的方法。 本文阐述了这些化合物用于治疗/预防神经障碍的用途及其合成方法。 本发明的示例性化合物抑制内源性单胺（例如多巴胺，5-羟色胺和去甲肾上腺素（例如来自突触间隙））的重摄取并调节一种或多种单胺转运蛋白。 还提供了掺入本发明化合物的药物制剂。