发明公开
- 专利标题： QUINOLONE COMPOUND
- 专利标题（中）： 喹诺酮化合物
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申请号： EP17202139.6申请日： 2012-08-30
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公开(公告)号： EP3318557A2公开(公告)日： 2018-05-09
- 发明人: ABUDUSAIMI, Mamuti , YE, Fangguo , SUN, Jiangqin , MIYAMOTO, Hisashi , CHENG, Jay-Fei , OKA, Daisuke
- 申请人： Otsuka Pharmaceutical Co., Ltd.
- 申请人地址： 2-9, Kanda Tsukasa-machi Chiyoda-ku Tokyo 101-8535 JP
- 专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址： 2-9, Kanda Tsukasa-machi Chiyoda-ku Tokyo 101-8535 JP
- 代理机构： J A Kemp
- 优先权： PCT/CN2011/001477 20110831; PCT/CN2012/001044 20120806
- 主分类号： C07D215/56
- IPC分类号： C07D215/56 ; C07D471/04 ; A61K31/47 ; A61K31/435
摘要：
The present invention provides a compound represented by the formula (I)
wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R 1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R 2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R 3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea.
wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R 1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R 2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R 3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea.
公开/授权文献
- EP3318557A3 QUINOLONE COMPOUND 公开/授权日：2018-07-11
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