发明公开
- 专利标题： NOVEL ENDOS MUTANT ENZYME
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申请号： EP16824539.7申请日： 2016-07-15
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公开(公告)号： EP3323886A1公开(公告)日： 2018-05-23
- 发明人: KAWAGUCHI, Yoshirou , NAKAMURA, Kensuke , SEKIGUCHI, Yukiko , IWAMOTO, Mitsuhiro
- 申请人： Daiichi Sankyo Company, Limited
- 申请人地址： 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo 103-8426 JP
- 专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人地址： 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo 103-8426 JP
- 代理机构： Arends, William Gerrit
- 优先权： JP2015141901 20150716
- 国际公布： WO2017010559 20170119
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N15/02 ; C12N15/09 ; C12P21/02 ; C12P21/08
摘要：
The present invention provides an EndoS mutant enzyme having an amino acid sequence of EndoS D233Q and further having a particular additional mutation and exhibiting a reduced hydrolysis activity, in comparison with the activity of EndoS D233Q, to an N-linked sugar chain (N297-linked sugar chain) linked to Asn at position 297 in IgG and a gene encoding the same.
公开/授权文献
- EP3323886B1 ENDOS MUTANT ENZYME 公开/授权日：2020-10-21
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