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公开(公告)号：EP3323886B1
公开(公告)日：2020-10-21
申请号：EP16824539.7
申请日：2016-07-15
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公开(公告)号：EP3252074A1
公开(公告)日：2017-12-06
申请号：EP16743511.4
申请日：2016-01-29
发明人： KATAGIRI, Takenobu , OSAWA, Kenji , TSUKAMOTO, Sho , TSUJI, Shinnosuke , KAWAGUCHI, Yoshirou , NAKAMURA, Kensuke
IPC分类号： C07K16/28 , A61K39/395 , A61K45/00 , A61P19/08 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08
CPC分类号： C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61P7/06 , A61P19/08 , A61P35/00 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： This application provides: an antibody which specifically binds to an ALK2 protein and has an activity of inhibiting BMP signal transduction mediated by ALK2; a method for producing the antibody; and a pharmaceutical composition comprising the antibody, for treating and/or preventing ectopic ossification and/or bone dysplasia, anemia, or diffuse intrinsic pontine glioma (DIPG).
摘要翻译： 本申请提供：特异性结合ALK2蛋白并具有抑制由ALK2介导的BMP信号转导活性的抗体; 生产抗体的方法; 以及包含该抗体的药物组合物，用于治疗和/或预防异位骨化和/或骨发育不良，贫血或弥散性内源脑桥胶质瘤（DIPG）。
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公开(公告)号：EP3323886A1
公开(公告)日：2018-05-23
申请号：EP16824539.7
申请日：2016-07-15
摘要： The present invention provides an EndoS mutant enzyme having an amino acid sequence of EndoS D233Q and further having a particular additional mutation and exhibiting a reduced hydrolysis activity, in comparison with the activity of EndoS D233Q, to an N-linked sugar chain (N297-linked sugar chain) linked to Asn at position 297 in IgG and a gene encoding the same.
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