- 专利标题： COMBINATION THERAPY USING PDK1 AND PI3K INHIBITORS
-
申请号： EP16828326.5申请日： 2016-07-15
-
公开(公告)号： EP3325100A1公开(公告)日： 2018-05-30
- 发明人: CASTEL, Pau , BASELGA, Jose, T. , SCALTRITI, Maurizio
- 申请人： Memorial Sloan-Kettering Cancer Center
- 申请人地址： 1275 York Avenue Box 524 New York, NY 10065 US
- 专利权人： Memorial Sloan-Kettering Cancer Center
- 当前专利权人： Memorial Sloan-Kettering Cancer Center
- 当前专利权人地址： 1275 York Avenue Box 524 New York, NY 10065 US
- 代理机构： Barker Brettell LLP
- 优先权： US201562194106P 20150717
- 国际公布： WO2017015152 20170126
- 主分类号： A61P35/00
- IPC分类号： A61P35/00 ; A61K31/437 ; A61K31/475 ; A61K39/395
摘要：
The present invention relates to methods and compositions for inhibiting growth and proliferation of cancer cells resistant to PI3K inhibition using a combination of PDK1, SGK1 and PI3K inhibitors. The present invention is also directed to methods of treating cancer in a subject exhibiting cancer cells resistant to PI3K inhibition, comprising administering inhibitors of PI3K in combination with inhibitors of PDK1 and/or SGK1 to the subject.
信息查询
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P35/00 | 抗肿瘤药 |
