- 专利标题: FUSED IMIDAZOLES AS MIDH1 INHIBITORS
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申请号: EP16757565.3申请日: 2016-07-14
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公开(公告)号: EP3325451A1公开(公告)日: 2018-05-30
- 发明人: PANKNIN, Olaf , HARTUNG, Ingo , REHWINKEL, Hartmut , NGUYEN, Duy , ZORN, Ludwig , HELFRICH, Petra , ZIMMERMANN, Katja , NEUHAUS, Roland
- 申请人: Bayer Pharma Aktiengesellschaft
- 申请人地址: Müllerstrasse 178 13353 Berlin DE
- 专利权人: Bayer Pharma Aktiengesellschaft
- 当前专利权人: Bayer Pharma Aktiengesellschaft
- 当前专利权人地址: Müllerstrasse 178 13353 Berlin DE
- 代理机构: BIP Patents
- 优先权: EP15177743 20150721
- 国际公布: WO2017012967 20170126
- 主分类号: C07D235/30
- IPC分类号: C07D235/30 ; C07D471/04 ; A61P35/00 ; A61K31/437 ; A61K31/4184
摘要:
The present invention relates to compounds of general formula (I) : in which R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
公开/授权文献
- EP3325451B1 FUSED IMIDAZOLES AS MIDH1 INHIBITORS 公开/授权日:2019-07-10
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