发明公开
- 专利标题： DNA SEQUENCE THAT INCREASES ODORANT RECEPTOR REPRESENTATION IN THE OLFACTORY SYSTEM
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申请号： EP16833802.8申请日： 2016-08-03
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公开(公告)号： EP3331990A1公开(公告)日： 2018-06-13
- 发明人: FEINSTEIN, Paul , D'HULST, Charlotte
- 申请人： Research Foundation Of The City University Of New York
- 申请人地址： 230 West 41st Street, 7th Floor New York, NY 10036 US
- 专利权人： Research Foundation Of The City University Of New York
- 当前专利权人： Research Foundation Of The City University Of New York
- 当前专利权人地址： 230 West 41st Street, 7th Floor New York, NY 10036 US
- 代理机构： Moré, Solveig Helga
- 优先权： US201562200312P 20150803; US201662312068P 20160323
- 国际公布： WO2017024028 20170209
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; C12N5/10 ; C12N5/079
摘要：
A genetically modified vertebrate is provided that has an enhanced sense due to an over representation of a predetermined odorant receptor. The vertebrate is genetically modified by introduction of DNA that comprises at least four sequential repeats of a sequence whose primary structure is at least 90% homologous with ACATAACTTTTTAATGAGTCT (SEQ ID NO: 1). The DNA causes a nearby odorant receptor coding sequence to be over represented in a singular gene choice fashion relative to a corresponding vertebrate that lacks the DNA.
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