- 专利标题： PIPERAZINE DERIVATIVE
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申请号： EP16833012.4申请日： 2016-08-02
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公开(公告)号： EP3333165A1公开(公告)日： 2018-06-13
- 发明人: SUGANE, Takashi , MAKINO, Takuya , YAMASHITA, Daisuke , YONETOKU, Yasuhiro , TANABE, Daisuke , MIHARA, Hisashi , ASAI, Norio , OSODA, Kazuhiko , SHIMIZU, Takafumi , MORITOMO, Hiroyuki , SUGASAWA, Keizo , MAENO, Kyoichi , HOSOGAI, Naomi
- 申请人： Astellas Pharma Inc.
- 申请人地址： 5-1, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： 5-1, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 代理机构： Hoffmann Eitle
- 优先权： JP2015154601 20150804
- 国际公布： WO2017022733 20170209
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/496 ; A61K31/501 ; A61P13/10 ; C07D403/06 ; C07D403/14 ; C07D405/14 ; C07D409/14 ; C07D417/14
摘要：
[Problem]
To provide a compound which can be used as an MC 4 receptor agonist.
[Means for Solution]
The present inventors have investigated MC 4 receptor agonists, and have found that a piperazine derivative has an action related to the agonists, thereby completing the present invention. That is, the piperazine derivative of the present invention has an MC 4 receptor agonistic action, and can be used as an agent for preventing or treating bladder and/or urinary tract diseases, in particular, underactive bladder, hypotonic bladder, acontractile bladder, detrusor underactivity, neurogenic bladder, urethral relaxation failure, detrusor-external urethral sphincter dyssynergia, and voiding dysfunctions in benign prostatic hyperplasia.
To provide a compound which can be used as an MC 4 receptor agonist.
[Means for Solution]
The present inventors have investigated MC 4 receptor agonists, and have found that a piperazine derivative has an action related to the agonists, thereby completing the present invention. That is, the piperazine derivative of the present invention has an MC 4 receptor agonistic action, and can be used as an agent for preventing or treating bladder and/or urinary tract diseases, in particular, underactive bladder, hypotonic bladder, acontractile bladder, detrusor underactivity, neurogenic bladder, urethral relaxation failure, detrusor-external urethral sphincter dyssynergia, and voiding dysfunctions in benign prostatic hyperplasia.
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