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公开(公告)号：EP3333165A1
公开(公告)日：2018-06-13
申请号：EP16833012.4
申请日：2016-08-02
申请人： Astellas Pharma Inc.
发明人： SUGANE, Takashi , MAKINO, Takuya , YAMASHITA, Daisuke , YONETOKU, Yasuhiro , TANABE, Daisuke , MIHARA, Hisashi , ASAI, Norio , OSODA, Kazuhiko , SHIMIZU, Takafumi , MORITOMO, Hiroyuki , SUGASAWA, Keizo , MAENO, Kyoichi , HOSOGAI, Naomi
IPC分类号： C07D401/14 , A61K31/496 , A61K31/501 , A61P13/10 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： [Problem]
To provide a compound which can be used as an MC 4 receptor agonist.
[Means for Solution]
The present inventors have investigated MC 4 receptor agonists, and have found that a piperazine derivative has an action related to the agonists, thereby completing the present invention. That is, the piperazine derivative of the present invention has an MC 4 receptor agonistic action, and can be used as an agent for preventing or treating bladder and/or urinary tract diseases, in particular, underactive bladder, hypotonic bladder, acontractile bladder, detrusor underactivity, neurogenic bladder, urethral relaxation failure, detrusor-external urethral sphincter dyssynergia, and voiding dysfunctions in benign prostatic hyperplasia.-
公开(公告)号：EP2150269B1
公开(公告)日：2012-11-21
申请号：EP08764256.7
申请日：2008-04-25
申请人： Astellas Pharma Inc.
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公开(公告)号：EP1957518B1
公开(公告)日：2015-12-09
申请号：EP06822844.4
申请日：2006-10-26
申请人： Astellas Pharma Inc.
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公开(公告)号：EP2204379A1
公开(公告)日：2010-07-07
申请号：EP08845535.7
申请日：2008-10-28
申请人： Astellas Pharma Inc.
发明人： TOMISHIMA, Masaki , MORIKAWA, Hiroshi , MAKINO, Takuya , IMANISHI, Masashi , KAYAKIRI, Natsuko , ASANO, Toru , ARAKI, Takanobu , NAKAGAWA, Toshiya
摘要： [Problems] To provide an antibacterial agent, particularly a novel polypeptide compound having an antifungal action.
[Means for Solution] As a result of an extensive study on a novel antifungal agent, the inventors have found that an excellent anti-deep-fungal activity is exhibited by introducing a cyclohexylmethylamino group or a piperidylmethylamino group as a partial structure of a natural polypeptide compound, and completed the present invetion.
The compound of the present invetion has an excellent antibacterial activity and is therefore useful as an agent for preventing or treating various fungal infections.摘要翻译： [课题]提供抗菌剂，特别是具有抗真菌作用的新型多肽化合物。 [溶液的方法]作为对新型抗真菌剂的广泛研究的结果，发明人已经发现通过引入环己基甲基氨基或哌啶基甲基氨基作为天然多肽的部分结构显示出优异的抗深部真菌活性 化合物，并完成了目前的研究。 本发明化合物具有优异的抗菌活性，因此可用作预防或治疗各种真菌感染的药剂。
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公开(公告)号：EP2150269A1
公开(公告)日：2010-02-10
申请号：EP08764256.7
申请日：2008-04-25
申请人： Astellas Pharma Inc.
发明人： YAMANAKA, Toshio , OHKI, Hidenori , ISHIDA, Junya , TODA, Ayako , HARAYAMA, Yu , MAKINO, Takuya , KUNIKAWA, Shigeki , MIZUNO, Hiroaki , OHTAKE, Hiroaki
摘要： The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
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公开(公告)号：EP1957518A1
公开(公告)日：2008-08-20
申请号：EP06822844.4
申请日：2006-10-26
申请人： Astellas Pharma Inc.
发明人： NEYA, Masahiro , YOSHIMURA, Seiji , KAMIJYO, Kazunori , MAKINO, Takuya , YASUDA, Minoru , YAMANAKA, Toshio , TSUJII, Eisaku , YAMAGISHI, Yukiko
摘要： The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising, the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
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