- 专利标题： CHIMERIC POLYPEPTIDE ASSEMBLY AND METHODS OF MAKING AND USING THE SAME
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申请号： EP16842718.5申请日： 2016-08-26
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公开(公告)号： EP3341009A2公开(公告)日： 2018-07-04
- 发明人: SCHELLENBERGER, Volker , YANG, Fan , THAYER, Desiree , SIM, Bee-cheng , WANG, Chia-wei
- 申请人： Amunix Operating Inc.
- 申请人地址： 500 Ellis Street Mountain View, CA 94043-2206 US
- 专利权人： Amunix Operating Inc.
- 当前专利权人： Amunix Operating Inc.
- 当前专利权人地址： 500 Ellis Street Mountain View, CA 94043-2206 US
- 代理机构： Kremer, Simon Mark
- 优先权： US201562211532P 20150828; US201562263319P 20151204; US201662278755P 20160114; US201662338285P 20160518; US201662363046P 20160715; US201662379673P 20160825
- 国际公布： WO2017040344 20170309
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K38/17 ; A61K38/24
摘要：
The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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