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公开(公告)号：EP3218390A2
公开(公告)日：2017-09-20
申请号：EP15858371.6
申请日：2015-11-11
CPC分类号： A61K47/551 , A61K47/6803 , A61K47/6855 , A61P35/00 , C07K14/00 , C07K2319/00 , C07K2319/01 , C07K2319/30 , C07K2319/50 , C07K2319/70 , C12N9/6421 , C12N15/70 , G01N2030/027
摘要： The present disclosure provides drug conjugate compositions, and compositions and methods for preparing and using the same. In some embodiments, the present invention relates to targeted conjugate compositions comprising cysteine-containing domains (CCD) linked to targeting moieties, extended recombinant polypeptides (XTEN)and peptide cleavable moieties, with pharmacologically active payload drugs cross-linked to cysteine residues, resulting in compositions that can be cleaved by proteases associated with target tissues. The invention also provides methods of making the targeted conjugate compositions and methods of using the targeted conjugate compositions.
摘要翻译： 本公开提供了药物缀合物组合物，以及用于制备和使用其的组合物和方法。 在一些实施方案中，本发明涉及包含与靶向部分连接的含半胱氨酸结构域（CCD），延伸重组多肽（XTEN）和肽可切割部分的靶向缀合物组合物，其中药理活性有效载荷药物与半胱氨酸残基交联，导致 可被与靶组织相关的蛋白酶切割的组合物。 本发明还提供了制备靶向缀合物组合物的方法和使用该靶向缀合物组合物的方法。
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公开(公告)号：EP3341009A2
公开(公告)日：2018-07-04
申请号：EP16842718.5
申请日：2016-08-26
CPC分类号： C07K16/2809 , A61K38/00 , A61K2039/507 , C07K16/30 , C07K2317/31 , C07K2317/60 , C07K2317/622 , C07K2319/01
摘要： The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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