- 专利标题: CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
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申请号: EP16777734.1申请日: 2016-08-25
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公开(公告)号: EP3341376A1公开(公告)日: 2018-07-04
- 发明人: PASTOR FERNÁNDEZ, Joaquín , MARTÍNEZ GONZÁLEZ, Sonia , BLANCO-APARICIO, Carmen , HERNÁNDEZ HIGUERAS, Ana Isabel , GÓMEZ DE LA OLIVA, Cristina Ana , RIVERO BUCETA, Virginia , RIESCO FAGUNDO, Rosario Concepción
- 申请人: Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III (F.S.P. CNIO)
- 申请人地址: Melchor Fermandez Almargro, 3 28029 Madrid ES
- 专利权人: Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III (F.S.P. CNIO)
- 当前专利权人: Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III (F.S.P. CNIO)
- 当前专利权人地址: Melchor Fermandez Almargro, 3 28029 Madrid ES
- 代理机构: Elzaburu S.L.P.
- 优先权: EP15382431 20150826
- 国际公布: WO2017033019 20170302
- 主分类号: C07D491/16
- IPC分类号: C07D491/16 ; A61K31/4745 ; A61P35/00 ; A61P25/00 ; A61P9/00 ; A61P37/00 ; A61P31/00 ; A61P29/00 ; A61P3/00 ; C07D491/22
摘要:
wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8 and/or Haspin kinase) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
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