专利检索 aee:"Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III (F.S.P. CNIO)" 第 1 页

1.

发明公开
CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS 审中-公开

公开(公告)号：EP3341376A1

公开(公告)日：2018-07-04

申请号：EP16777734.1

申请日：2016-08-25

申请人： Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III (F.S.P. CNIO)

发明人： PASTOR FERNÁNDEZ, Joaquín , MARTÍNEZ GONZÁLEZ, Sonia , BLANCO-APARICIO, Carmen , HERNÁNDEZ HIGUERAS, Ana Isabel , GÓMEZ DE LA OLIVA, Cristina Ana , RIVERO BUCETA, Virginia , RIESCO FAGUNDO, Rosario Concepción

IPC分类号： C07D491/16 , A61K31/4745 , A61P35/00 , A61P25/00 , A61P9/00 , A61P37/00 , A61P31/00 , A61P29/00 , A61P3/00 , C07D491/22

CPC分类号： C07D491/147 , A61K31/437 , A61K31/4545 , A61K31/5377 , A61K45/06 , A61P35/00 , C07D491/16 , C07D491/22

摘要： wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8 and/or Haspin kinase) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.