发明公开
- 专利标题： INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 AND TDO) AND THEIR USE IN THERAPY
-
申请号： EP16839685.1申请日： 2016-08-25
-
公开(公告)号： EP3350188A1公开(公告)日： 2018-07-25
- 发明人: PALMER, Brian Desmond , CHING, Lai-Ming
- 申请人： AUCKLAND UNISERVICES LIMITED
- 申请人地址： Level 10, 70 Symonds Street Auckland NZ
- 专利权人： AUCKLAND UNISERVICES LIMITED
- 当前专利权人： AUCKLAND UNISERVICES LIMITED
- 当前专利权人地址： Level 10, 70 Symonds Street Auckland NZ
- 代理机构： Watson, Robert James
- 优先权： NZ15711514 20150827
- 国际公布： WO2017034420 20170302
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; A61K31/437 ; A61P9/04 ; A61P13/12 ; A61P15/00 ; A61P25/00 ; A61P27/12 ; A61P29/00 ; A61P31/00 ; A61P35/00
摘要：
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
公开/授权文献
信息查询
