专利检索 ap:("AUCKLAND UNISERVICES LIMITED") AND inv:"CHING, Lai-Ming" 第 1 页

1.

发明公开
INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 AND TDO) AND THEIR USE IN THERAPY 审中-公开

公开(公告)号：EP3350188A1

公开(公告)日：2018-07-25

申请号：EP16839685.1

申请日：2016-08-25

申请人： AUCKLAND UNISERVICES LIMITED

发明人： PALMER, Brian Desmond , CHING, Lai-Ming

IPC分类号： C07D498/04 , A61K31/437 , A61P9/04 , A61P13/12 , A61P15/00 , A61P25/00 , A61P27/12 , A61P29/00 , A61P31/00 , A61P35/00

CPC分类号： C07D498/04 , A61K31/437 , A61K45/06

摘要： Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.