发明公开
- 专利标题： ASGR INHIBITORS
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申请号： EP16781931.7申请日： 2016-09-28
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公开(公告)号： EP3356415A1公开(公告)日： 2018-08-08
- 发明人: NIOI, Paul , COWARD, Peter , MURAWSKY, Christopher , PIPER, Derek, E. , GARCES, Fernando , ZHANG, Jun , LI, Yang , CHAN, Brian, Mingtung
- 申请人： Amgen Inc.
- 申请人地址： Law-Patent Operations M/S 28-2-C One Amgen Center Drive Thousand Oaks, California 91320 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： Law-Patent Operations M/S 28-2-C One Amgen Center Drive Thousand Oaks, California 91320 US
- 代理机构： Dörries, Hans Ulrich
- 优先权： US201562234546P 20150929; US201562259553P 20151124; US201662319740P 20160407
- 国际公布： WO2017058944 20170406
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; A61P9/00 ; A61P3/06
摘要：
Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
公开/授权文献
- EP3356415B1 ASGR INHIBITORS FOR REDUZING CHOLESTEROL LEVELS 公开/授权日：2024-05-01
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