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公开(公告)号:EP4196584A2
公开(公告)日:2023-06-21
申请号:EP21766066.1
申请日:2021-08-12
申请人: Amgen Inc.
发明人: MURRAY, Justin K. , ZHANG, Jun , HOMANN, Oliver , LONG, Jason C. , MEADE, Bryan
IPC分类号: C12N15/113 , A61K31/713
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公开(公告)号:EP3504333A1
公开(公告)日:2019-07-03
申请号:EP17764943.1
申请日:2017-08-25
申请人: Amgen Inc.
发明人: OLLMANN, Michael , LI, Yang , ZHANG, Jun , BISWAS, Kaustav , HOMANN, Oliver , MIRANDA, Leslie P. , MURRAY, Justin K. , WU, Bin , YOON, Oh Kyu , ALLEN, John Gordon , NETIROJJANAKUL, Chawita , CHENG, Yuan
IPC分类号: C12N15/113
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公开(公告)号:EP4435105A2
公开(公告)日:2024-09-25
申请号:EP24173045.6
申请日:2016-09-28
申请人: Amgen Inc.
发明人: NIOI, Paul , COWARD, Peter , MURAWSKY, Christopher , PIPER, Derek, E. , GARCES, Fernando , ZHANG, Jun , LI, Yang , CHAN, Brian, Mingtung
IPC分类号: C12N15/113
CPC分类号: C07K16/28 , C07K2317/3020130101 , C07K2317/7720130101 , A61P9/10 , A61P9/04 , C07H21/02 , A61K39/3955 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2317/9420130101 , C12N15/1138 , C12N2310/1420130101
摘要: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
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公开(公告)号:EP3618864A1
公开(公告)日:2020-03-11
申请号:EP18729833.6
申请日:2018-05-07
申请人: Amgen Inc.
发明人: ABEL, Jeff , CUI, Lingwen , GOSWAMI, Devrishi , HUH, Joon , JAGANNATHAN, Bharadwaj , KANAPURAM, Sekhar , MCAULEY, Arnold , SCHNEIDER, Michael , SETHURAMAN, Ananthakrishnan, G. , TREUHEIT, Michael , ZHANG, Jun
IPC分类号: A61K39/395 , C07K16/28 , A61K47/00
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公开(公告)号:EP4341161A1
公开(公告)日:2024-03-27
申请号:EP22731368.1
申请日:2022-05-19
申请人: Amgen Inc.
发明人: GOSWAMI, Devrishi , ZHANG, Jun , PIEDMONTE, Deirdre , PADMAKUMAR, Vikashni , LE, David , SANTOS, Maria, Raquel , QI, Wei
IPC分类号: B65B3/00
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公开(公告)号:EP4157353A1
公开(公告)日:2023-04-05
申请号:EP21740288.2
申请日:2021-05-28
申请人: Amgen Inc.
发明人: IP, Anna , PATEL, Ketaki , TALLEY, Clea , TREUHEIT, Michael J. , ZHANG, Jun
IPC分类号: A61K39/395 , A61P7/00 , C07K16/18
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公开(公告)号:EP3356415A1
公开(公告)日:2018-08-08
申请号:EP16781931.7
申请日:2016-09-28
申请人: Amgen Inc.
发明人: NIOI, Paul , COWARD, Peter , MURAWSKY, Christopher , PIPER, Derek, E. , GARCES, Fernando , ZHANG, Jun , LI, Yang , CHAN, Brian, Mingtung
IPC分类号: C07K16/28 , A61K39/395 , A61P9/00 , A61P3/06
CPC分类号: C07K16/2851 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61P9/04 , A61P9/10 , C07H21/02 , C07K14/705 , C07K16/28 , C07K2317/30 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C12N15/1138
摘要: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
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